中国医疗设备2017，Vol.32Issue(1)：18-21,25,5.DOI:10.3969/j.issn.1674-1633.2017.01.005
在体测量大鼠缺血性脑损伤引起的脑组织电阻抗变化及组织形态学对照研究
Electrical Impedance Variation Measurement of Rat Ischemic Brain Injuries and Tissue Morphology Control Study
摘要
Abstract
Objective To study the impedance variation of ischemic stroke and its’ secondary brain edema to distinguish the two types of brain injuries.Methods Two-electrode method was used to measure impedance of rats’ brain in vivo continuously. Then we analyzed the impedance variation over time, and the microscopic morphology parameters were analyzed by Image-Pro Plus as comparison and verification of the impedance variation.Results Electrical impedance of rat ischemic brain has risen 10%~20% after 6~8 h of brain ischemia, where the peak of the electrical impedance shows out. Then the impedance reduced over time. And there was a good correlation between the impedance variation and the microscopic morphology parameters.Conclusion Bioelectrical impedance measurement technique can be used to distinguish ischemic stroke and secondary brain edema, as indicated by the impedance variation of rat ischemic brain over time.关键词
心脑血管疾病/缺血性脑卒中/脑水肿/生物电阻抗测量/微观形态学分析Key words
cardiac-cerebral vascular disease/ischemic stroke/brain edema/bioelectrical impedance measurement/microscopic morphology analysis分类
信息技术与安全科学引用本文复制引用
宋佳丽,杨琳,亢君君,李昊庭,董秀珍,付峰..在体测量大鼠缺血性脑损伤引起的脑组织电阻抗变化及组织形态学对照研究[J].中国医疗设备,2017,32(1):18-21,25,5.基金项目
国家自然科学基金（51477176）；军队重大项目（AW S14C006）。 （）
