疑难病杂志2017，Vol.16Issue(2)：113-116,4.DOI:10.3969/j.issn.1671-6450.2017.02.002
远端缺血预处理对肥胖急性心肌梗死患者急诊PCI术后脂肪素水平的影响
The influence of RICP on levels of apelin in obesity AMI patients following PCI treatment
布伦 1朱海龙 1袁建 1刘超颖 1丁仲如1
作者信息
- 1. 100091 北京，解放军第309医院心血管病中心
- 折叠
摘要
Abstract
Objective To observe the effect of remote ischemic adaptation ( RIPC) on the level of serum visfatin (Apelin) in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI).Methods For-ty eight obesity AMI patients from June 2013 to June 2014 were enrolled in the 309 th Hospital of Chinese People Liberation Army and they were divided into two groups equally and randomly: RIPC group and non RIPC group .All the AMI patients were received PCI treatment .The levels of apelin , NT-proBNP and cTnI were measured before PCI and one week after PCI . All the patients were following a 2 years investigation for MACE rate.Results The contents of apelin[(61.4 ±11.2)ng/ml vs.(33.7 ±6.5)ng/ml, t =2.760, P =0.005] and cTnI[(77.1 ±8.6)ng/ml vs.(4.2 ±1.1) ng/ml, t =2.632, P =0.006] in RICP group were significantly decreased one week after PCI treatment .However, the levels of apelin [(62.7 ± 9.6) ng/ml vs.(79.3 ±14.1)ng/ml, t =2.127, P =0.021] and NT-proBNP [(357.6 ±31.5) pg/ml vs.(412.3 ± 72.8) pg/ml, t =1.992, P =0.027] were increased after PCI in non RIPC group .Correlation analysis showed that RIPC was negatively related with △apelin ( r =-0.698, P <0.05) and MACE ( r =-0.611, P <0.05).MACE was negative-ly associated with △apelin ( r =-0.653, P <0.05).Conclusion RIPC can improve long term outcome in obesity patients with AMI by regulating serum levels of apelin .关键词
远端缺血预处理/肥胖/心肌梗死,急性/脂肪素Key words
Remote ischemic preconditioning/Obesity/Myocardial infarction ,acute/Apelin引用本文复制引用
布伦,朱海龙,袁建,刘超颖,丁仲如..远端缺血预处理对肥胖急性心肌梗死患者急诊PCI术后脂肪素水平的影响[J].疑难病杂志,2017,16(2):113-116,4.
