中风与神经疾病杂志2017，Vol.34Issue(1)：43-47,5.
责任性颅内动脉粥样硬化性狭窄致首发缺血性脑卒中解剖模式与发病机制的关系
Relationship between topographic patterns and mechanisms in intracranial atherosclerotic stenosis related first-ev-er Ischemic Stroke
摘要
Abstract
Objective To evaluate the relationship between topographic patterns and mechanism in ischemic stroke with intracranial atherosclerotic stenosis ( ICAS ) .Methods We retrospectively investigated 261 patients who had ICAS with ischemic stroke.The patients’ characteristics were reviewed,ischemic patterns were divided into single (corticosub-cortical,cortical,subcortical lesion),scattered,multiple lesions.Stroke mechanisms were categorized as artery to artery em-bolism (A-A),in situ thrombotic occlusion (STO),local branch occlusion (LBO),hemodynamic impairment (HI),and multiple mechanisms.Results In all of the patients who had ICAS with ischemic stroke ,single subcortical (41.4) lesions were most commonly seen in all the lesion patterns ,the most frequent lesion mechanism was LBO (66.3).There was a sta-tistically significant association between topographic patterns on DWI and different stroke mechanisms (r=0.384,P =0.001).LBO was related with subcortical lesions (r=0.805,P=0.001),scattered,multiple lesions in unilateral anterior circulation,multiple lesions in posterior circulation were especially association with A-A (r=0.853,P=0.001;r=0.860, P=0.001;r=0.281,P=0.001) and multiple mechanisms (r=0.792,P=0.001;r=0.883,P=0.001;r=0.213,P=0.001).Conclusion Topographical patterns were helpful to verify etiology mechanism in ICAS with ischemic stroke .关键词
缺血性脑卒中/颅内动脉粥样硬化性狭窄/解剖模式/发病机制/弥散加权成像Key words
Ischemic stroke/Intracranial atherosclerotic stenosis/Topographic patterns/Mechanisms/DWI分类
医药卫生引用本文复制引用
王炎强,孙绍洋,王玉鸽,伍爱民,杨渝,戴永强,陆正齐,胡学强..责任性颅内动脉粥样硬化性狭窄致首发缺血性脑卒中解剖模式与发病机制的关系[J].中风与神经疾病杂志,2017,34(1):43-47,5.基金项目
山东省医药卫生科技发展计划项目 （）
