中国保健营养2016，Vol.26Issue(33)：6-7,2.
中国克罗恩病病人多基因多态性研究
Polymorphism of multiple genes in Chinese Crohn's disease patients
陈军 1李杨 1顾国胜 1王革非 1范朝刚1
作者信息
- 1. 江苏南京南京总医院普通外科研究所，江苏 南京 210000
- 折叠
摘要
Abstract
Background and Aims:Crohn’s disease(CD)is a multifactorial disorder with a pivotal role of the genetic component.Single nucleotide polymorphisms have been shown to be associated with a severe clinical course in CD.The purpose of this study was to identify associations between thesepolymorphisms and the clinical courses of CD in the Chinese population. Methods One hundred patients with CD and 190 healthy individuals were genotyped for 12 polymorphisms by restriction fragment length polymorphism analysis.Results The genotype frequen-cy of the PstI polymorphism did not dif er between patients and controls.The A al ele was higher in CD patients than in controls(61% vs 52%,P =0.047,odds ratio [OR]=1.423,95%confidence interval [CI]:1.004 – 2.015).Furthermore,this polymorphism was higher in the penetrating or fistula surgery of CD patients than in controls(63% vs 52%,P =0.049,OR =1. 530,95% CI:1.001 – 2.337;Table 4).But there was no significant dif erence between the penetrating or fistula surgery patients and no surgery patients(P =0.673,OR =0.883,95% CI:0.495 – 1.574).There were nopolymorphismsin others genes.Conclusion This study reported that the al ele A of PstI polymorphism was the association between CD and HSP70 -2 gene in the Chinese population.It was also association between penetrating or fistula surgery of CD and HSP70 -2 gene in the Chinese population.关键词
克罗恩病/基因多态性研究分类
医药卫生引用本文复制引用
陈军,李杨,顾国胜,王革非,范朝刚..中国克罗恩病病人多基因多态性研究[J].中国保健营养,2016,26(33):6-7,2.
