中国临床医学2016，Vol.23Issue(6)：705-709,5.DOI:10.12025/j.issn.1008-6358.2016.20160832
原发性肝细胞肝癌射频消融术前血清HBeAg水平与术后复发的相关性
Correlationship between preoperative serum HBeAg level and tumor recurrence after radiofrequency ablation in patients with hepatocellular carcinoma
周颖婷 1谢晓莺 1干育红 1葛宁灵 1陈漪 1任正刚 1张岚1
作者信息
- 1. 复旦大学附属中山医院肝肿瘤内科，上海 200032
- 折叠
摘要
Abstract
Objective:To investigate the correlation between preoperative serum HBeAg level and tumor recurrence after radiofrequency ablation (RFA) in patients with hepatocellular carcinoma (HCC) .Methods :Clinical data of 391 cases with hepatitis B background of HCC underwent RFA from June 2006 to June 2012 in Zhongshan Hospital ,Fudan University were analyzed retrospectively .According to preoperative levels of HBeAg ,patients were divided into HBeAg positive group (n=112) and HBeAg negative group (n=279) ,with regular followed‐up after operation .The correlationship between HBeAg before RFA and tumor recurrence after RFA was analyzed .Results:The median recurrence‐free survival time (RFS) was (23 .00 ± 1 .99) months in HBeAg positive group ,and the median RFS was (31 .00 ± 3 .49) months in HBeAg negative group (P=0 .002) .Cox proportional hazard regression analysis showed that preoperative AFP level (HR 139 .3 ,95% CI 1 .052‐1 .845 ,P=0 .021) ,serum HBV‐DNA level (HR 1 .402 ,95% CI 1 .013‐1 .939 ,P=0 .041) ,and HBeAg levels (HR 1 .389 , 95% CI 1 .017‐1 .896 , P=0 .039) were the independent risk factors for survival in hepatitis B background HCC patients after RFA .Conclusions :Preoperative serum HBeAg level in patients with primary HCC is closely related to postoperative tumor recurrence .It is an independent risk factor for recurrence of HCC after RFA .关键词
原发性肝细胞肝癌/射频消融术/HBeAgKey words
primary hepatocellular carcinoma/radiofrequency ablation/HBeAg分类
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周颖婷,谢晓莺,干育红,葛宁灵,陈漪,任正刚,张岚..原发性肝细胞肝癌射频消融术前血清HBeAg水平与术后复发的相关性[J].中国临床医学,2016,23(6):705-709,5.
