中国临床医学2016，Vol.23Issue(6)：720-724,5.DOI:10.12025/j.issn.1008-6358.2016.20160996
原发性肝细胞肝癌中核不均一核糖核蛋白A1的定位及临床意义
The location and significance of heterogeneous nuclear ribonucleoprotein A 1 in hepatocellular carcinoma
摘要
Abstract
Objective:To investigate the location of heterogeneous nuclear ribonucleoprotein A 1 (hnRNP A1 ) ,and to analyze the relationship between the location and clinicopathologic feature and its prognostic significance in hepatocellular carcinoma (HCC) .Methods : The location of hnRNP A1 was studied in an independent cohort of 323 HCC patients by immunohistochemistry ,the hnRNP A1 location and clinicopathologic feature and its prognostic significance in HCC were concluded .Results:For hnRNP A1 ,there was weak‐to‐moderate intensity immunoreactivity with nuclear expression in normal liver ,while showed cytoplasmic and nuclear loaction in HCC .The cytoplasmic loaction of hnRNP A1 is significantly correlated with poor prognosis of HCC patients after operation .Conclusions :The hnRNP A1 is a great independent prognostic indicator , which can accurately predict the poor outcome of HCC patients after surgery .关键词
核不均一核糖核蛋白A1/肝癌/预后Key words
heterogeneous nuclear ribonucleoprotein A1/hepatocellular carcinoma/prognosis分类
医药卫生引用本文复制引用
周正君,王晓怡,陈二宝,胡志强,周少来,周俭,樊嘉,代智..原发性肝细胞肝癌中核不均一核糖核蛋白A1的定位及临床意义[J].中国临床医学,2016,23(6):720-724,5.基金项目
国家自然科学基金青年基金（81401926，81502485）． Supported by National Natural Science Youth Foundation of China （81401926，81502485）． （）
