中国临床医学2016，Vol.23Issue(6)：731-734,4.DOI:10.12025/j.issn.1008-6358.2016.20160076
胃癌组织miR-155的表达及其与临床预后的关系
Expression of miR-155 in gastric cancer and its prognostic significance
周明 1马建明1
作者信息
- 1. 扬州市第一人民医院普通外科，扬州 225001
- 折叠
摘要
Abstract
Objective: To discuss the expression of miR‐155 and its clinical significance in gastric carcinoma . Methods :One hundred and sixteen pairs of human gastric carcinoma tissues were obtained from patients who underwent surgical resection .The level of miR‐155 in 116 gastric cancer tissues and the adjacent normal gastric tissues were detected by real‐time fluorescent quantitative reverse transcriptase‐polymerase chain reaction (RT‐qPCR) ,and the association between miR‐155 expressions with clinicopathological factors and prognostic values were explored .Immunohistochemical staining for PTEN in all pathological specimens from gastric cancer biopsy was performed .The correlationship between PTEN and miR‐155 expression was analyzed .Results:The expression of miR‐155 in gastric cancer tissues was higher than that of adjacent normal gastric tissues (P<0 .001) .The up‐regulated expression of miR‐155 was associated with TNM stage ,invasion level and lymph node metastases ( P< 0 .05 ) . Kaplan‐Meier analysis demonstrated that high miR‐155 expression clearly predicted poorer progression free survival (PFS ,P<0 .001) and overall survival (OS) (P<0 .001) within three years .PTEN expression was negatively correlated to miR‐155 expression .Gastric cancer tissues with higher miR‐155 expression disclosed lower PTEN expression (P< 0 .001) .Conclusions : MiR‐155 may plays a pivotal role in the development and progression of gastric carcinoma ,and it may be the potential biomarker in the diagnosis and prognosis of gastric carcinoma .关键词
胃癌/miR-155/PT EN/临床意义/预后Key words
gastric carcinoma/miR-155/PTEN/clinical significance/prognosis分类
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周明,马建明..胃癌组织miR-155的表达及其与临床预后的关系[J].中国临床医学,2016,23(6):731-734,4.
