中国全科医学2017，Vol.20Issue(1)：45-50,6.DOI:10.3969/j.issn.1007-9572.2017.01.010
慢性肺源性心脏病患者生命质量与临床客观指标的相关性研究
Correlation between Quality of Life and Values of Clinical Objective Indicators in Chronic Pulmonary Heart Disease
摘要
Abstract
Objective To investigate the correlation between quality of life and values of clinical objective indicators in chronic pulmonary heart disease( CPHD). Methods One hundred and forty acute exacerbated CPHD patients admitted to Department of Respiratory Medicine,First Affiliated Hospital of Kunming Medical University and Department of Respiratory Medicine,Second Affiliated Hospital Kunming Medical University from January 2010 to March 2011 were enrolled in this study. A questionnaire survey was conducted in the patients,which included the basic conditions,and QLICD - CPHD(V2. 0),one of the quality of life instruments,covering 4 domains,such as PHD,PSD,SOD and SPD. The values of patients' clinical objective indicators consisted of routine blood tests,routine urine examination,blood biochemical tests,blood gas analysis and pulmonary function tests were also collected from the medical records. The relationship between total score, the domains scores of QLICD - CPHD(V 2. 0)and the results of clinical objective indicators were analyzed via statistical methods of simple correlation and canonical correlation. Results The standard scores of PHD,PSD,SOD and SPD and the total score of quality of life in CPHD patients were(54. 5 ± 13. 1), (59. 5 ± 16. 1), (63. 0 ± 15. 5), (59. 0 ± 16. 6), (58. 9 ± 12. 5),respectively. Simple correlation analysis results showed that levels of chloridion and pH had a positive linear correlation whereas partial pressure of carbon dioxide(PCO2 )and temperature( TEMP)had a negative linear correlation with PHD scores( P ﹤ 0. 05);levels of chloridion and red blood cell count were positively and linearly while TEMP was negatively and linearly correlated with PSD scores (P ﹤ 0. 05);specific gravity of urine presented a negative linear correlation while partial pressure of oxygen( PO2 )and FEV1 / FVC ratio demonstrated a positive linear correlation with SOD scores( P ﹤ 0. 05 );the levels of ALT,AST,total bilirubin and chloridion had a positive linear correlation while TEMP had a negative linear correlation with SPD scores( P ﹤0. 05);the levels of ALT,sodion,and chloridion were positively and linearly while TEMP was negatively and linearly correlated with the total score of quality of life( P ﹤ 0. 05). A total of 4 pairs of canonical variables were obtained through canonical correlation analysis,of which,the canonical coefficient r1 of 1 pair of canonical variables was 0. 411,P ﹤ 0. 05. Correlation analysis of canonical variables with original variables demonstrated that,levels of sodion and chloridion presented positive correlations while PCO2 and TEMP showed negative correlations with PHD,PSD,SPD scores. Conclusion The scores of PHD of CPHD patients are lowest of the 4 domains. The levels of sodium,chlorine,PCO2 and TEMP are strongly correlated with quality of life,so in the treatment of CPHD,these indicators should be given significant attention in order to improve the quality of life.关键词
肺心病/生活质量/临床客观指标/相关性Key words
Pulmonary heart disease/Quality of life/Clinical objective indicators/Correlation分类
医药卫生引用本文复制引用
阮景昊,周甲东,万崇华,赵芝焕,吴斌,黎东明,陈敏..慢性肺源性心脏病患者生命质量与临床客观指标的相关性研究[J].中国全科医学,2017,20(1):45-50,6.基金项目
国家自然科学基金资助项目（30860248、71373058）；广东省科技计划项目 （）
