中国全科医学2017，Vol.20Issue(1)：51-55,61,6.DOI:10.3969/j.issn.1007-9572.2017.01.011
代谢正常肥胖患者的代谢异常发生风险及影响因素研究
Incidence and Influencing Factors of Metabolic Disorders in Obese Patients with Normal Metabolism
摘要
Abstract
Objective To study the incidence and risk factors of metabolic disorders in metabolically healthy obese (MHO)patients. Methods From April to August 2011,we selected 3 communities from Luzhou using simple random sampling method. And by issuing recruitment brochures at the community health service centers of the 3 communities,we recruited 1 374 residents who had normal metabolism and volunteered to participate in this study. In accordance with the abdominal circumference, the included residents were divided into MHO group( n = 286)and metabolically healthy non - obese( MHNO)group( n= 1 088). We used standardized questionnaires to collect the general data of the residents,and gave them physical examination and laboratory tests. The incidences of metabolic disorders of both groups were recorded at 3 - year follow - up. Results The incidence of metabolic disorders was higher in the MHO group than that in the MHNO group〔38. 8% (111 / 286)vs. 25. 1%(273 / 1 088),OR(95% CI) = 1. 891(1. 437,2. 489),P ﹤ 0. 05〕. As stratified by gender,when compared with MHNO group,higher incidences of metabolic disorders were observed in both males and females in the MHO group(P ﹤ 0. 05). As stratified by age,higher incidences of metabolic disorders were noted in both aged 40 to 55 years and aged 56 to 70 years in MHO group compared with the MHNO group(P ﹤ 0. 05). However,the incidence of metabolic disorders in residents aged 71 to 93 years in the MHO group was not significantly different from that in the MHNO group( P ﹥ 0. 05). There were no statistically significant difference in terms of sex,mean age,occupation,history of smoking,history of drinking,waist circumference,hip circumference, levels of systolic pressure, diastolic pressure, glutamyltranspetidase ( GGT ), glycosylated hemoglobin (HbA1c ),total cholesterol( TC)and low - density lipoprotein cholesterol( LDL-C)between the pateints with metabolic disorders and those without in the MHO group(P ﹥ 0. 05). In the MHO group,the pateints with metabolic disorders had higher BMI,higher levels of fasting plasma glucose( FPG),blood glucose concentration at 2 h of an oral glucose tolerance test (OGTT)and triacylglycerol(TG),but lower level of high - density lipoprotein cholesterol(HDL-C)(P ﹤ 0. 05). Results of multivariate Logistic regression analysis suggested that TG and HDL-C levels were the influencing factors for metabolic disorders occurred in the patients of MHO group( P ﹤ 0. 05). Conclusion The conditions of MHO group were not optimistic with a higher incidence of metabolic disorders compared with the MHNO group. Higher TG and lower HDL-C levels were the risk factors for metabolic disorders occurring in patients in the MHO group.关键词
肥胖症/代谢障碍/影响因素分析Key words
Obesity/Metabolism disorders/Root cause analysis分类
医药卫生引用本文复制引用
刘丹,万沁..代谢正常肥胖患者的代谢异常发生风险及影响因素研究[J].中国全科医学,2017,20(1):51-55,61,6.基金项目
国家代谢性疾病临床医学研究中心项目 （）
