中国全科医学2017，Vol.20Issue(1)：71-75,5.DOI:10.3969/j.issn.1007-9572.2017.01.015
高龄2型糖尿病患者下肢动脉硬化闭塞症的危险因素研究
Risk Factors of Lower Extremity Atherosclerotic Occlusive Disease in Elderly Patients with Type 2 Diabetes Mellitus
摘要
Abstract
Objective To explore the risk factors for lower extremity atherosclerotic occlusive disease(LEAOD)in elderly patients with type 2 diabetes mellitus(T2DM). Methods We performed a retrospective analysis of 187 elderly patients with T2DM who were hospitalized in Department of Geriatrics,the First Affiliated Hospital of Chongqing Medical University, between October 2014 and October 2015. These patients were divided into two groups based on the value of ankle brachial index (ABI):LEAOD group(ABI≤0. 9,n = 85)and non - LEAOD group(ABI ﹥ 0. 9,n = 102). Comparisons of general data, including basic situation,complication/ inheritance,blood pressure and laboratory examination indexes were made between the two groups. Risk factors for LEAOD were analyzed by multivariate Logistic regression. Results Compared with the patients in the non - LEAOD group,patients in the LEAOD group were older,and they had longer duration of disease,higher levels of blood uric acid,cystatin C,total cholesterol,glycosylated hemoglobin(HbA1c )(P ﹤ 0. 05),but lower levels of hemoglobin and albumin(P ﹤ 0. 05). The differences in height,body mass,BMI,levels of systolic and diastolic blood pressure,pulse pressure,serum creatinine,triacylglycerol,high - density lipoprotein(HDL)and low - density lipoprotein(LDL)and fasting plasma glucose between the two groups showed no statistical significance(P ﹥ 0. 05). No statistically significant differences were found in the proportion of males,proportion of patients with smoking history,proportion of patients with drinking history, incidences of stroke,coronary heart disease,diabetic nephropathy,retinopathy and albuminuria between the two groups(P ﹥0. 05). Patients in the LEAOD group had higher incidences of hypertension,carotid atherosclerosis,peripheral neuropathy than those in the non - LEAOD group did( P ﹤ 0. 05). Multivariate Logistic regression analysis revealed that course of disease, HbA1c and hypertension were the independent risk factors while albumin was the independent protective factor for LEAOD occurring in elderly patients with T2DM(P ﹤ 0. 05). Conclusion The morbidity of LEAOD is significantly higher in the elderly patients with T2DM. For elderly patients with T2DM, especially those with long course of disease, high HbA1c level, hypertension,or hypoproteinemia,we should enhance controlling blood glucose level and early comprehensive treatment,in order to prevent the occurrence and deterioration of LEAOD.关键词
老年人,80以上/糖尿病,2型/闭塞性动脉硬化/危险因素Key words
Aged,80 and over/Diabetes mellitus,type 2/Arteriosclerosis obliterans/Risk factors分类
医药卫生引用本文复制引用
杨敏,邓辉胜..高龄2型糖尿病患者下肢动脉硬化闭塞症的危险因素研究[J].中国全科医学,2017,20(1):71-75,5.基金项目
国家临床重点专科建设项目 （）
