摘要
Abstract
Background Many diabetic patients suffer from acute cerebral infarction,and the levels of blood glucose are related to the morbidity and severity of acute cerebral infarction. Antithrombin Ⅲ is a physiological anticoagulant factor, which contributes to the increased risk of thrombotic diseases when its activity reduces. Glycated albumin,reflecting the 2 to 3 weeks inside level of blood glucose,plays a key role in diabetes - related atherosclerosis. However,there have been few studies on the relationship between glycated albumin levels and antithrombin Ⅲ or cerebral infarction. Objective To compare the activity of antithrombin Ⅲ of diabetic patients combined with acute cerebral infarction under different glycated albumin levels. Methods Two hundred and thirty - nine diabetic patients combined with acute cerebral infarction who were hospitalized in Beijing Chao - yang Hospital, Capital Medical University from May to December in 2014 were chosen as research objects. According to the glycated albumin levels of subjects,they were divided into group A(glycated albumin < 17. 0% ,88 cases),and group B( glycated albumin ≥ 17. 0% ,151 cases). The activity of plasma antithrombin Ⅲ was measured immediately after admission,and the levels of fasting blood glucose,total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)and glycated albumin were measured on the day after admission. Results The levels of fasting blood glucose,TG and LDL-C in group B were significantly higher than those in group A(P < 0. 05). The activity of antithrombin Ⅲ in group B〔(103. 8 ± 9. 2)% 〕was significantly lower than that in group A〔(106. 6 ± 10. 9)% ,t = 2. 017,P = 0. 045〕. The activity of antithrombin Ⅲ was negatively associated with levels of fasting blood glucose and glycated albumin(r = - 0. 188, - 0. 165,P < 0. 05),and positively related to HDL-C(r = 0. 200,P <0. 05). Multiple linear regression analysis showed that fasting plasma glucose( b = - 1. 149)and HDL-C( b = 7. 056)were independent predictors of the activity of antithrombin Ⅲ in diabetic patients combined with acute cerebral infarction(P < 0. 05). Conclusion The increased glycated albumin level of diabetic patients combined with acute cerebral infarction have a lower activity of plasma antithrombin Ⅲ.关键词
糖尿病/脑梗死/糖化清蛋白/抗凝血酶ⅢKey words
Diabetes mellitus/Brain infarction/Glycated albumin/Antithrombin Ⅲ分类
医药卫生
