中国全科医学2017，Vol.20Issue(3)：299-303,5.DOI:10.3969/j.issn.1007-9572.2017.03.007
改善膳食模式对北京市房山区张坊村中老年高血压患者炎性指标的影响
Effects of Dietary Pattern Improvement on the Levels of Inflammatory Markers in Middle-aged and Older People with Hypertension in Zhangfang Village of Fangshan District of Beijing
王佳 1洪忠新 1武力 1丁冰杰 1顾中一 1葛智文 1柳露 1毕研霞 1李伟1
作者信息
- 1. 100050 北京市，首都医科大学附属北京友谊医院营养科
- 折叠
摘要
Abstract
Objective To explore the effect of dietary pattern improved by supplementing anti ― atherosclerosis therapeutic powder on the levels of inflammatory markers in middle―aged and older people with hypertension in Zhangfang Village of Fangshan District of Beijing. Methods From 27th June to 11th October 2015,we selected 30 overweight or obese patients with grade―1 hypertension meeting the inclusion criteria as the participants of this study from the database of 245 middle―aged and older villagers in Zhangfang Village of Fangshan District of Beijing. We randomized the patients into group 1 ( n﹦15 )and group 2(n﹦15). And a cross―over intervention study was conducted on the groups which consisted of 3 stages lasting for 14 weeks. Stage 1 ( 6 weeks ):group 2 kept the original dietary pattern but group 1 took anti ― atherosclerosis therapeutic powder. Stage 2(2 weeks):group 2 kept the original dietary pattern,but group 1 recovered the original dietary pattern. Stage 3 (6 weeks):group 2 took anti ― atherosclerosis therapeutic powder,group 1 kept the original dietary pattern. A total of 24 subjects(11 in group 1 and 13 in group 2)completed the trial finally. Before the trial(T0),at the end of the 6th week(T1) and 14th week(T2)of trial,the levels of inflammatory markers including nuclear factor NF-κB,soluble intercellular adhesion molecules ―1 ( sICAM-1 ), soluble vascular cell adhesion molecule 1 ( sVCAM-1 ), endothelium ― selectin ( E-Selectin ), Integrin,Adiponectin,high―sensitivity C―reactive protein( hs-CRP),fasting blood glucose( FBG),fasting insulin( FIN) and homeostatic model assessment of insulin resistance index(HOMA-IR)were measured in the subjects. Results In group 1, sICAM-1 at T1 was higher than that at T2,NF-κB,Integrin at T0 were higher than those at T2(p 〈0. 05). In group 2, sICAM-1 at T1 was higher than that at T2,and sICAM-1,sVCAM-1 at T0 were higher than those at T2(p〈0. 05). At T0, T1 and T2,there were no significant differences between the two groups in NF-κB,sICAM-1,sVCAM-1,E-Selectin,Integrin, Adiponectin,hs-CRP and HOMA-IR(p〉0. 05). Conclusion For overweight or obese middle―aged and older hypertension patients,improving the dietary pattern via controlling the total energy intake supplemented by taking anti ― atherosclerosis therapeutic powder,can lower the blood pressure to a certain degree by decreasing the levels of inflammation markers long ―termly.关键词
高血压/饮食习惯/炎症Key words
Hypertension/Food habits/Inflammation分类
医药卫生引用本文复制引用
王佳,洪忠新,武力,丁冰杰,顾中一,葛智文,柳露,毕研霞,李伟..改善膳食模式对北京市房山区张坊村中老年高血压患者炎性指标的影响[J].中国全科医学,2017,20(3):299-303,5.
