中国全科医学2017，Vol.20Issue(5)：538-542,5.DOI:10.3969/j.issn.1007-9572.2017.05.007
法舒地尔治疗老年慢性肺源性心脏病临床疗效及其机制的随机对照研究
Efficacy and Mechanism of Action of Fasudil in the Treatment of Elderly Patients with Chronic Pulmonary Heart Disease:A Randomized Controlled Study
摘要
Abstract
Objective To evaluate the efficacy and mechanism of action of fasudil in the treatment of elderly patients with chronic pulmonary heart disease( CPHD). Methods The subjects enrolled in this study were 76 elderly patients with CPHD admitted to Department of Respiratory Medicine,Second Hospital of Xi′ an from October 2014 to March 2015 by a prospective method. And they were divided into the treatment group(n = 38)and the control group(n = 38)by random number table method. Based on the conventional medical therapy,the treatment group additionally received intravenous drip of fasudil injection,and the control group received intravenous drip of 0. 9% sodium chloride injection. And the treatment for both groups lasted for 14 days. Blood pressure,heart rate(HR),blood gas analysis〔partial pressure of oxygen(PaO2 ),partial pressure of carbon dioxide(PaCO2 )〕,systolic pulmonary arterial pressure(sPAP)were measured before and after treatment. Levels of hypersensitive C - reactive protein( hs-CRP)and N - terminal pro - brain natriuretic peptide( NT-proBNP)were measured before,at the 7th and 14th days after treatment,respectively. And adverse events occurred during treatment were observed. Results Of the patients in the control group,1 died of heart failure,and 1. 3% dropped out of the study. No significantly statistical differences were found in terms of systolic and diastolic blood pressure and HR between the two groups before and after treatment(P > 0. 05). Before treatment,no significant differences were observed in PaO2 ,PaCO2 and sPAP between the two groups(P > 0. 05),but after treatment,PaO2 was elevated and PaCO2 and sPAP were decreased in the treatment group(P <0. 05). Treatment method and time exerted interaction effect on levels of hs-CRP and NT-proBNP( P < 0. 05). Treatment method led to remarkable main effect on levels of hs-CRP and NT-proBNP(P < 0. 05). Treatment time also had significant main effect on levels of hs-CRP and NT-proBNP( P < 0. 05). Before treatment,levels of hs-CRP and NT-proBNP in the treatment group did not differ from those in the control group significantly(P > 0. 05),but at the 7th and 14th days after treatment,levels of hs-CRP and NT-proBNP in the treatment group were lowered(P < 0. 05). During the treatment,only a few patients had some side effects such as dizziness(3 in treatment group and 2 in control group)and headache(1 in treatment group and 1 in control group),but the symptoms disappeared when the medicine was stopped. Conclusion The treatment of fasudil in regular doses can effectively improve the PaO2 ,reduce PaCO2 ,sPAP,levels of hs-CRP and NT-proBNP in elderly patients with CPHD,do not increase adverse reactions.关键词
肺心病/法舒地尔/C 反应蛋白质/利钠肽,脑/随机对照试验Key words
Pulmonary heart disease/Fasudil/C - reactive protein/Natriuretic peptide,brain/Randomized controlled trial分类
医药卫生引用本文复制引用
卜丽娜,宋爱玲,贾卫红,杨栋才,韩燕燕..法舒地尔治疗老年慢性肺源性心脏病临床疗效及其机制的随机对照研究[J].中国全科医学,2017,20(5):538-542,5.基金项目
西安市卫生局科研项目 （）
