中国全科医学2017，Vol.20Issue(6)：694-698,5.DOI:10.3969/j.issn.1007-9572.2017.06.012
凝血与补体级联反应信号通路对艾滋病湿热内蕴证发病的影响
Impact of Signal Path of Coagulation and Complement Cascades Reaction for AIDS Patients with Syndrome of Interior Dampness-heat
摘要
Abstract
Objective To make clear the expression differences of the protein levels in the syndrome of interior dampness - heat of AIDS,and explore the role of signal path of coagulaton and complement cascades reaction in the nature of TCM syndrome. Methods By random cluster sampling principle,48 AIDS patients(25 with syndrome of Qi deficiency of lung and spleen of AIDS was Qi deficiency of lung and spleen of AIDS group,23 with syndrome of interior dampness - heat of AIDS was interior dampness - heat of AIDS group)were enrolled in October 2014,and non HIV infected individuals with similar demographic data in the same area were taken as the control group. The serum samples of all the subjects were studied with iTRAQ techniques,and the differential proteins were annotated by signal pathway. Results Compared with Qi deficiency of lung and spleen of AIDS group,the expression of α1 - antitrypsin and complement C4bp was down - regulated in interior dampness - heat of AIDS group. Compared with the control group,the expression of α1 - antitrypsin,complement C4bp,α - 2 macroglobulin and human - binding serine lectin protease 2 was up - regulated and the expression of C1r subcomponent complement,complement factor B,apolipoprotein B variant was down - regulated in interior dampness - heat of AIDS group. These proteins activated in coagulation and complement cascades reaction signal path. Conclusion The pathogenesis of AIDS patients suffering from syndrome of dampness - heat may be achieved through coagulation and complement cascades reaction signal path,and the differential proteins in this signal path can be used as potential drug targets for clinical treatment of AIDS.关键词
获得性免疫缺陷综合征/湿热/蛋白质组学Key words
Acquired immunodeficiency syndrome/Dampness - heat/Proteomics分类
医药卫生引用本文复制引用
张海燕,张淼,吕顺武,高亮,李建智,谢世平..凝血与补体级联反应信号通路对艾滋病湿热内蕴证发病的影响[J].中国全科医学,2017,20(6):694-698,5.基金项目
国家十二五重大专项---HIV/ AIDS 中医证候转录组学研究（2012ZX10005001-005）；河南省高等学校重点科研项目---基于差异基因建立 HIV/ AIDS 湿热内蕴证判别模型（15A360038）；河南中医学院博士科研基金---艾滋病中医发病机制“艾毒伤元”假说的物质基础的文献及实验研究 （）
