中国动物传染病学报Issue(6)：50-55,6.
柔嫩艾美耳球虫2个抗药株的抗药性评估
RESISTANT ASSESSMENT OF MADURAMICIN RESISTANT STRAIN AND DICLAZURIL RESISTANT STRAIN OF EIMERIATENELLA
摘要
Abstract
In order to detect the drug resistance of Eimeria tenella (E. tenella) maduramicin resistant strain, diclazuril resistant strain and drug sensitive strain to three drugs which include diclazuril, decoquinate and maduramicin, the body-testing method was used for evaluating the effect, including anticoccidial index (ACI), reduction of lesion scores (RLS), relative oocyst production (ROP) and percent of optimum anticoccidial activity (POAA). The results revealed that drug sensitive strain was sensitive to the three drugs and all indicators was negative. Maduramicin resistant strain was serious resistance to maduramicin and all indicators was positive, but it was sensitive to diclazuril and decoquinate and all indicators was negative. Diclazuril resistant strain was serious resistance to diclazuril and all indicators was positive, it was also middle resistance to maduramicin and two indicators was positive, but it was sensitive to decoquinate and all indicators was negative. These results show that the two drug-resistant strains of E.tenella that be propagated and kept for more than 10 years in the laboratory have obvious resistance to maduramicin and diclazuril, respectively, which will indicate that the method that E. tenella propagated and saved in the lab is feasible and the drug-resistance of durg-induced strain can be inherited stably, and it will provide an experimental foundation for drug-resistant mechanism research.关键词
柔嫩艾美耳球虫/地克珠利/马杜拉霉素/耐药性Key words
Eimeriatenella/diclazuril/maduramicin/drug resistance分类
农业科技引用本文复制引用
谢雨翔,杨志远,黄兵,韩红玉,赵其平,王自文,董辉,徐帅兵,朱顺海,崔晓霞,唐敏..柔嫩艾美耳球虫2个抗药株的抗药性评估[J].中国动物传染病学报,2016,(6):50-55,6.基金项目
中央级公益性科研院所基本科研业务费专项资金项目 （）
