摘要
Abstract
Objective To analyze etiology and clinical characteristics of acute liver failure in Nanchang region of Jiangxi province, and study the value of the model for end-stage liver disease (MELD) score in the assessment of prognosis of acute liver failure (ALF). Methods The clinical data of 47 adult patients with acute liver failure in our hospital from January 2006 to December 2014 were retrospectively analyzed, includ-ing etiology, clinical characteristics, treatment and prognosis, etc. Results Hepatitis B virus (HBV) infection was the most common cause of acute liver failure in Nanchang, accounting for 40.4% of the cases (19/47);followed by drug induced ALF in 10 cases (21.3%), of which anti-tuberculosis drugs caused ALF in 4 cases, Chinese herbal medicine caused ALF in 3 cases, anti-tumor drugs induced ALF in 2 cases, antipyretic and analgesic drug induced ALF in 1 case. Combined HBV and HEV infection was found in 3 cases, accounting for 6.4% of the group; 1 case had acute fatty liver of pregnancy, 2 cases had heatstroke, 2 cases had mush-room poisoning, 5 cases (10.6%) had unknown etiology. In this group, 34 cases died, the mortality rate was 72.3%. There were significant differences in ALB, TBIL, PT, AFP, BLA levels and MELD score between the survival group and the death group ( <0.05). The higher the MELD score, the higher the mortality. However, there was no significant difference in AST or ALT level ( >0.05). At the time of admission, the ROC of MELD score was 0.881. When the cut-off value was 30.2, the 47 patients were divided into the group of MELD score ≤30.2 and the group of MELD score >30.2, the difference of mortality was statistically signifi-cant (χ²=-4.793, =0.000), the mortality of the patients with admission MELD score ≤30.2 was significantly lower. Conclusions Infection of hepatitis B virus is the main cause of acute liver failure in Nanchang. The MELD score has a certain value in evaluating the prognosis of acute liver failure.关键词
南昌地区/急性肝衰竭/病因/临床特点Key words
Nanchang area/acute liver failure/etiology/clinical characteristics分类
医药卫生
