中国现代医学杂志2017，Vol.27Issue(2)：26-30,5.DOI:10.3969/j.issn.1005-8982.2017.02.004
盆炎丸对解脲支原体感染小鼠血清IL-2、IL-4表达的影响
Effects of Penyan pills on expressions of serum IL-2 and IL-4 in mice infected by Ureaplasma urelytium
陈青 1刘文娥 2张婉妮 3周意3
作者信息
- 1. 湖南中医药大学第一附属医院 感染科，湖南 长沙 410007
- 2. 湖南中医药大学第一附属医院 妇产科，湖南 长沙 410007
- 3. 湖南中医药大学，湖南 长沙 410007
- 折叠
摘要
Abstract
Objective To observe the effect of Penyan pills on the expressions of IL-2 and IL-4 in mice infected by (UU), and to discuss the immune mechanism of Penyan pills. Methods Forty 8-week old female BALB/c mice in SPF level were selected, and randomly divided into two groups:the blank group with 8 mice and the model-making group with 32 mice. The model-making group was subdivided into three groups randomly:the model group, the TCM group and the Western medicine group, which were perfused respectively with saline, Penyan pills and Clarithromycin. Mouse vaginal secretions were cultured for UU after 14 days, and the expression levels of IL-2 and IL-4 were observed. Results The clearance rate of the Western medicine group was 100%, while the clearance rate of the TCM group was 78%. The content of IL-2 was the highest in the Western medicine group,then the TCM group, the lowest in the model group. The IL-2 content in the Western medicine group and the TCM group was significantly different from that in the blank group and the model group ( < 0.01), while there was no significant difference in the IL-2 content between the blank group and the model group or between the Western medicine group and the TCM group ( > 0.05). The content of IL-4 was the lowest in the TCM group, then the Western medicine group, the highest in the model group. The IL-4 content in the blank group was not significantly different from that in the model group, the Western medicine group or the TCM group ( > 0.05). The IL-4 content in the model group was significantly different from that in the TCM group ( <0.01) and the Western medicine group ( <0.05). But there was no significant difference in the IL-4 content between the Western medicine group and the TCM group ( > 0.05). Conclusions Penyan pills could enhance the clearance of UU and play a role in immune regulation by increasing serum IL-2 level and decreasing IL-4 level in mice.关键词
盆炎丸/解脲支原体/BALB/c小鼠/白细胞介素2(IL- 2)/白细胞介素4(IL- 4)Key words
Penyan pill/Ureaplasma urelytium/BALB/c mouse/IL-2/IL-4分类
医药卫生引用本文复制引用
陈青,刘文娥,张婉妮,周意..盆炎丸对解脲支原体感染小鼠血清IL-2、IL-4表达的影响[J].中国现代医学杂志,2017,27(2):26-30,5.
