中国现代医学杂志2017，Vol.27Issue(2)：71-75,5.DOI:10.3969/j.issn.1005-8982.2017.02.013
重组人血管内皮抑素治疗老年性肝癌腹腔积液患者的近远期生存质量评估*
Rh-endostatin combined with chemotherapy in management of malignant pleural effusion in elderly patients with liver cancer:clinical efficacy and quality of life*
摘要
Abstract
Objective To evaluate the efficacy and quality of life of Rh-endostatin combined with chemotherapy in the management of malignant pleural effusion in elderly patients with liver cancer: clinical efficacy and toxicity. Methods A total of 125 patients with stage Ⅲ and Ⅳ liver cancer were treated with Rh-endostatin combined with chemotherapy from January 2013 to December 2015 were selected. The patients were randomly divided into two groups. The observation group were treated with Rh-endostatin combined with chemotherapy, and the control group only with chemotherapy. Clinical efficacy and short-term and long-term quality of life were assessed. Results In the observation group, the application of Rh-endostatin resulted in complete response in 16 cases (24.6%), partial response in 34 cases (52.3%), stable disease in 11 cases (16.9%) and progressive disease in 4 cases (6.2%). Within the study group, complete response rate (CR+PR) was 76.9% and the control rate (CR+PR+SD) was 93.8%, which were higher than those of the control group (χ²= 18.402, =0.000). The effective rate of the observation group was significantly higher than that of the control group (χ² = 16.159, = 0.000). The 1-year, 3-year and 5-year overall survival rates were 86.2%, 30.8%, and 18.5%respectively by Kaplan-Meier method, which were significantly better than those of the control group (Log Rank test, χ² = 3.859, = 0.049). Short and long-term quality of life in the observation group was better than that in the control group ( = 18.645, = 0.041). In this study, a comparative analysis of prognostic factors showed that Rh-endostatin and KPS score>80 points significantly affected the survival time and survival rate of the patients after treatment. Conclusions The combination of Rh-endostatin and chemotherapy results in high local control of malignant pleural effusion, few complications and good survival quality in the elderly patients with liver cancer.关键词
重组人血管内皮抑素/化疗/肝癌/控制率/生存时间Key words
Rh-endostatin/chemotherapy/liver cancer/local control rate/survival time分类
医药卫生引用本文复制引用
刘兴强,王霞,刘超..重组人血管内皮抑素治疗老年性肝癌腹腔积液患者的近远期生存质量评估*[J].中国现代医学杂志,2017,27(2):71-75,5.基金项目
*基金项目2013年中国博士后科学基金（No2013M530880）；2013年中国博士后科学基金 （）
