中国畜牧兽医2017，Vol.44Issue(1)：59-64,6.DOI:10.16431/j.cnki.1671-7236.2017.01.008
牛血红蛋白源抗菌肽P3及其类似肽的生物信息学分析
Bioinformatics Analysis of Antimicrobial Peptide P3 from Bovine Hemoglobin and Its Analogs
摘要
Abstract
To provide basic information for researching the biological function of antimicrobial peptide P3 from bovine hemoglobin and its analogs (JH-0,JH-1,JH-2 and JH-3),tools on line were utilized to analyze some bioinformatic features of these five peptides.The results showed that the isoelectric point of these five peptides were all more than 8.00.All of these five peptides had positive charge,no transmembrane domain,no signal peptide sequence,no glycosylation sites,were hydrophobins and located at extracellular.The secondary structure of peptide P3 and JH-2 had α-helix andβ-sheet,JH-3 was all α-helix,while JH-0 and JH-1 were coil.Peptide P3, JH-2 and JH-3 had a glycosylation site at the thirteenth site of amino acid (Thr,T),respective-ly.Based on these results,we conjectured that antimicrobial peptide P3 and its analogs could kill bacteria through the interaction with cell wall or cell membrane.关键词
牛血红蛋白/抗菌肽/类似肽/生物信息学Key words
bovine hemoglobin/antimicrobial peptide/analogous peptide/bioinformatics分类
农业科技引用本文复制引用
李杰,杭柏林,秦爱建,钱琨,胡建和..牛血红蛋白源抗菌肽P3及其类似肽的生物信息学分析[J].中国畜牧兽医,2017,44(1):59-64,6.基金项目
国家自然科技基金项目（31372469、31672559）；河南省高校科技创新团队支持计划（15IRTSTHN）；河南科技学院高层次人才启动项目 （）
