中国药房2017，Vol.28Issue(4)：469-471,472,4.DOI:10.6039/j.issn.1001-0408.2017.04.10
氢氧化镧对大鼠慢性肾衰高磷血症的改善作用研究
Study on Improvement Effect of Lanthanum Hydroxide on Chronic Renal Failure Hyperphosphatemia in Rats
摘要
Abstract
OBJECTIVE:To study the improvement effect of lanthanum hydroxide on chronic renal failure (CRF) hyperphos-phatemia in rats. METHODS:CRF hyperphosphatemia rat model were induced and then randomly divided into model group,lan-thanum carbonate group [0.3 g/(kg·d)],calcium carbonate group [4.2 g/(kg·d)] and lanthanum hydroxide high-dose,medium-dose and low-dose groups [1.5,1,0.5 g/(kg·d)] with 10 rats in each group. They were given adenine 0.2 g/(kg·d)intragastrically in the morning,and then given relevant medicine intragastrically in the afternoon;a week later,they stopped taking adenine but con-tinued to take relevant medicine for 22 d. 10 normal rats were selected as normal control group. General examination was conduct-ed,and renal coefficient,serum contents of calcium,phosphorus,PTH,creatinine(Scr)and usea nitrogen(BUN)were detected after last medication as well as renal pathological change. RESULTS:Compared with normal control group,model group showed CRF sign,renal coefficient,the contents of phosphorus,PTH,Scr and BUN were increased,while the content of calcium was de-creased(P<0.01);renal section showed obvious pathological characteristics. Compared with model group,CRF sign of rats were improved in lanthanum carbonate group,calcium carbonate group and lanthanum hydroxide groups. The renal coefficient (except for lanthanum hydroxide high-dose group),serum contents of phosphorus(except for calcium carbonate group),PTH(except for lanthanum hydroxide low-dose group and calcium carbonate group),Scr(except for lanthanum hydroxide low-dose group and calci-um carbonate group)and BUN were all decreased,while serum content of calcium and calcium-phosphorucs product(only in calci-um carbonate group)was increased(P<0.05 or P<0.01). There was no statistical significance in other difference. The renal sec-tion pathological characteristics were improved. CONCLUSIONS:Lanthanum hydroxide can improve renal function and reduce the level of serum phosphorus in CRF hyperphosphatemia model rats.关键词
氢氧化镧/慢性肾衰/高磷血症/大鼠Key words
Lanthanum hydroxide/Chronic renal failure/Hyperphosphatemia/Rat分类
医药卫生引用本文复制引用
武燕,刘丹丹,张弘,苏苗,崔雅婷,马子兴,赵国君,李刚..氢氧化镧对大鼠慢性肾衰高磷血症的改善作用研究[J].中国药房,2017,28(4):469-471,472,4.基金项目
国家自然科学基金资助项目（No.81260650，81560685）；内蒙古自然科学基金资助项目（No.2014BS0805）；内蒙古医科大学科技百万工程基金项目 （）
