中国药房2017，Vol.28Issue(4)：487-489,3.DOI:10.6039/j.issn.1001-0408.2017.04.15
小酸枣汤对小鼠自主活动及睡眠时间影响的拆方研究
Study on the Effects of Disassembled Formulation of Xiaosuanzao Decoction on Spontaneous Motion and Sleep Time in Mice
摘要
Abstract
OBJECTIVE:To investigate the effects of Xiaosuanzao decoction on spontaneous motion and sleep time in mice, and to study its disassembled formulation. METHODS:Seven ingredients of Xiaosuanzao decoction were selected as the influential factors, including Ziziphus jujuba, Poria cocos, Ligusticum chuanxiong, Anemarrhena asphodeloides, Glycyrrhiza uralensis, Zingiber officinale and Cortex cinnamoni. Two levels of with or without were designed for each factor,and the experiment was ar-ranged according to L8(27) orthogonal test table. The effects of Xiaosuanzao decoction and each ingredient on spontaneous motion within 2 min and sleep time induced by superthreshold dosage of pentobarbital sodium were compared by visual analysis method and analysis of variance. RESULTS:Z. jujube and A. asphodeloides were the main active ingredients of Xiaosuanzao decoction on spontaneous motion;Z. jujube was the main active ingredient of Xiaosuanzao decoction on sleep time induced by superthreshold dosage of pentobarbital sodium. CONCLUSIONS:Xiaosuanzao decoction can inhibit spontaneous motion and prolong sleep time in-duced by superthreshold dosage of pentobarbital sodium,and Z. jujube is the main ingredient of Xiaosuanzao decoction.关键词
小酸枣汤/拆方研究/正交试验/自主活动/睡眠时间/小鼠Key words
Xiaosuanzao decoction/Disassembled formulation/Orthogonal test/Spontaneous motion/Sleep time/Mice分类
医药卫生引用本文复制引用
张立峰,刘灿仿..小酸枣汤对小鼠自主活动及睡眠时间影响的拆方研究[J].中国药房,2017,28(4):487-489,3.基金项目
河北省教育厅河北省高等学校科学技术研究项目 （）
