中国药房2017，Vol.28Issue(4)：530-532,533,4.DOI:10.6039/j.issn.1001-0408.2017.04.27
丹皮酚-羟丙基-β-环糊精包合物的制备及处方工艺优化
Preparation of Paeonol-HP-β-cyclodextrin Inclusion Compound and Its Prescription Technology Optimiza-tion
摘要
Abstract
OBJECTIVE:To prepare paeonol-HP-β-cyclodextrin (PAE-HP-β-CD) inclusion compound and to optimize its pre-scription technology. METHODS:PAE-HP-β-CD was prepared by freeze drying method and validated. Using inclusion rate as in-dex,main drug-accessory ratio,inclusion time,inclusion temperature and stirring speed as factors,the preparation technology was optimized by central composite design-response surface methodology. RESULTS:Prepared PAE-HP-β-CD underwent phase transfor-mation. The optimal inclusion technology was as follows as main drug-accessory ratio of 3.39∶1,inclusion temperature of 50 ℃, inclusion time of 3.2 h, stirring speed of 350 r/min. Relative error between measured value (87.46%) and predicted value (89.12%) of inclusion rate was 1.86%(n=6). CONCLUSIONS:PAE-HP-β-CD inclusion compound is prepared successfully, and its prescription technology is stable and feasible.关键词
丹皮酚/羟丙基-β-环糊精/包合物/星点设计-响应面法/制备工艺/优化Key words
Paeonol/HP-β-CD/Inclusion compound/Central composite design-response surface methodology/Prescription technology/Optimization分类
医药卫生引用本文复制引用
郑欣,杨培洪,何霖,陈希,程模,游必波..丹皮酚-羟丙基-β-环糊精包合物的制备及处方工艺优化[J].中国药房,2017,28(4):530-532,533,4.基金项目
垫江县科技计划项目 （）
