中国药理学通报2017，Vol.33Issue(1)：1-9,9.DOI:10.3969/j.issn.1001-1978.2017.01.001
中枢神经系统ERK信号通路在药物成瘾中的作用机制研究进展
Research Progress on mechanism of ERK signaling pathway in drug addiction
摘要
Abstract
Drug addiction is a chronic relapsing brain disease. Repeated drug exposure can cause neuroadaptations in major brain circuitries,leading to compulsive drug consumption behav-ior and relapse after abstinence.Many studies have found that intercellular signaling cascades mediated central nervous system remodeling in the rewarding circuitry and addiction associated neuroplasticity of learning and memory are important molecular mechanism of drug addiction.Studies show that extracellular sig-nal-regulated kinase (ERK)is associated with drug-mediated psychomotor activity,rewarding properties and relapse of drug seeking behaviors.Therefore,this article has reviewed the role of ERK signaling pathway in drug addiction.Research on the role of ERK signaling pathway in drug addiction will provide im-portant theoretical foundation for in-depth understanding of the molecular mechanism of drug addiction and shine a light on new molecular targets and treatment strategies for drug addiction.关键词
药物成瘾/神经可塑性/奖赏效应/觅药行为/复吸/ERKKey words
drug addiction/neural plasticity/reward effect/drug seeking/relapse/ERK引用本文复制引用
张盼盼,徐文锦,刘惠芬..中枢神经系统ERK信号通路在药物成瘾中的作用机制研究进展[J].中国药理学通报,2017,33(1):1-9,9.基金项目
浙江省自然科学基金面上项目资助项目（No LY14H310002）；宁波市科技计划项目（No 2013C50033，2015 C110026）；国家重点基础研究发展计划资助项目 （）
