中国药理学通报2017，Vol.33Issue(1)：10-13,4.DOI:10.3969/j.issn.1001-1978.2017.01.002
HIF-1α和 HIF-2α在低氧性肺动脉高压中的不同作用研究进展
Advances in differential roles of HIF-1αand HIF-2αin the pathogenesis of hypoxic pulmonary hypertension
摘要
Abstract
Hypoxia-induced factors(HIFs)are the main regula-tors for the response of hypoxic environment.They are involved in hypoxia-related lung tissue cell damage and abnormal cell pro-liferation,among which,HIF-1αand HIF-2αplay the most im-prominant roles.This paper reviews the current researches of HIF-1αand HIF-2α,focusing on their structural and functional similarities and diversities,as well as their roles in the patho-genesis of hypoxic pulmonary hypertension.关键词
低氧诱导因子-1α/低氧诱导因子-2α/低氧/低氧性肺动脉高压/调控/功能Key words
HIF-1α/HIF-2α/hypoxia/hypoxic pulmonary hy-pertension/regulation/function引用本文复制引用
邓軻,张旭,喻珊珊..HIF-1α和 HIF-2α在低氧性肺动脉高压中的不同作用研究进展[J].中国药理学通报,2017,33(1):10-13,4.基金项目
国家自然科学基金资助项目（No 81200043，81000078）；广东省自然科学基金项目 （）
