中国药理学通报2017，Vol.33Issue(1)：22-26,27,6.DOI:10.3969/j.issn.1001-1978.2017.01.005
HPA轴编程及其有关表观遗传修饰机制与创伤后应激障碍发病的研究进展
Epigenetic pathogenesis of post-traumatic stress disorder based on the HPA aixs
摘要
Abstract
Currently,the worldwide frequency of catastrophic e-vents has made post-traumatic stress disorder (PTSD)a major public health problem.As a stress-related psychiatric disorder, PTSD is considered as the result of interaction between gene and environments (especially early life adversity).The epigenetics plays an important role in PTSD pathogenesis.Due to the core role of hypothalamic-pituitary-adrenal (HPA)axis,the research on the relationship between HPA axis epigenetics and PTSD pathogenesis in recent years was reviewed in the paper so as to provide references and thinking of the prevention and therapy for PTSD in the future.关键词
创伤后应激障碍/下丘脑-垂体-肾上腺轴/早期负性经历/易感基因/表观遗传学/DNA甲基化Key words
post-traumatic stress disorder/hypothalamic-pituita-ry-adrenal axis/early life adversity/susceptible gene/epigenet-ics/DNA methylation引用本文复制引用
王宣尹,吴丽丽,严灿..HPA轴编程及其有关表观遗传修饰机制与创伤后应激障碍发病的研究进展[J].中国药理学通报,2017,33(1):22-26,27,6.基金项目
国家自然科学基金资助项目（No 30873207）；广东省自然科学基金资助项目（No 2016A030313648）；国家级大学生创新创业训练计划资助项目 （）
