中国药理学与毒理学杂志2016，Vol.30Issue(12)：1254-1263,10.DOI:10.3867/j.issn.1000-3002.2016.12.004
帕金森病脑脊液和血液生物标志物的研究进展
Overview of cerebrospinal fluid and blood candidate biomarkers in Parkinson disease
摘要
Abstract
Parkinson disease(PD)is a common,progressive and disabling neurodegenerative movement disorder. Diagnosis of PD depends on clinical history and physical examination,but misdi⁃agnosis is common in early stages because of similar symptoms to other movement disorders. which is why biomarkers are urgently needed to accurately diagnose PD,especially in the early stages of PD, and find new drug targets. This review discusses the curient research of the PD candidate biomarkers from cerebrospinal fluid and blood in terms of PD pathogenesis. We have found that dihy⁃droxyphenylacetic acid,alpha- synuclein and its related proteins in Lewy bodies,8- hydroxy deoxy⁃guanosine,uric acid,interleukin and neurotrophic factors are potential biomarkers. They participate in different stages of PD. In order to enhance the accuracy of early diagnosis and efficacy of drugs evalua⁃tion,we are to use multiple biomarkers rather than a single biomarker,in combination with different biologic pathways of biomarkers,neuroimaging as well as clinical symptoms.关键词
帕金森病/生物标志物/脑脊液/血液Key words
Parkinson disease/biomarker/cerebrospinal fluid/blood分类
医药卫生引用本文复制引用
崔丹丹,王晓良,彭英..帕金森病脑脊液和血液生物标志物的研究进展[J].中国药理学与毒理学杂志,2016,30(12):1254-1263,10.基金项目
国家科技重大专项（2012ZX09301002-004）；新药作用机制研究与药效评价北京市重点实验室资助（BZ0150）@@@@The project supported by National of Science and Technology Mega Project of China （2012ZX09301002-004）；and Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study （）
