中国医学创新2016，Vol.13Issue(35)：21-23,3.DOI:10.3969/j.issn.1674-4985.2016.35.005
竹叶黄酮抑制大鼠脑海马的炎症反应减轻糖尿病大鼠认知功能障碍
Bamboo Leaf Flavone Alleviates Cognitive Deficit Through Inhibiting Inflammation in Hippocampus in Diabetic Rats
摘要
Abstract
Objective:To study the effect of Bamboo Leaf Flavone on cognitive deficit in diabetic rats and the relevant mechanism.Method:A total of 40 male SD rats were fed with high glucose and high fat diet for 4 weeks,then rats were received a single intraperitoneal injection of Streptozotocin(STZ,50 mg/kg) to induced diabetic mice.36 rats who were successful model were divided into three groups:DM group,DM+BLF group and DM+CO group,12 rats in each group.Meanwhile,12 age-match rat were selected as CON group.After Bamboo Leaf Flavone were treated with 12 weeks,Morris water maze(MWM) was used to evaluated the effect of Bamboo Leaf Flavone on the cognitive deficits in diabetic rats.Nissl’s staining was used to detected the implication of Bamboo Leaf Flavone in hippocampal neuronal damage in diabetic rats.Moreover,we used WB method to tested the expression of Interleukin-6(IL-6),Cyclooxygenase-2(COX-2) and tumor necrosis factor-α(TNF-α) in hippocampus of each group.Result:Bamboo Leaf Flavone could ameliorate cognitive deficit,reduce the hippocampus neuronal damage and inhibit the expression of inflammatory factors in diabetic rats.Conclusion:Bamboo Leaf Flavone alleviate cognitive deficit and protect hippocampal neuron in diabetic rats through inhibiting inflammation.关键词
竹叶黄酮/糖尿病大鼠/认知障碍/海马/炎症Key words
Bamboo Leaf Flavone/Diabetic rats/Cognitive deficit/Hippocampal neuron/Inflammation引用本文复制引用
周晓燕,应长江,王珊珊,宋远见..竹叶黄酮抑制大鼠脑海马的炎症反应减轻糖尿病大鼠认知功能障碍[J].中国医学创新,2016,13(35):21-23,3.基金项目
国家自然科学基金 （）
