摘要
Abstract
Objective:To study the relationship between TLR4,CD14 and patients with sjogren’s syndrome labial gland secretion tissue damage and.Method:Through the labial gland tissue in patients with sjogren's syndrome immunohisto chemical and reverse transcription polymerase chain reaction,to detect the TLR4,CD14 protein and mRNA expression.Result:(1)CD14 and TLR4 expression in labial gland organization in sjogren's syndrome group was obviously higher,the control group did not see labial gland tissue TLR4,CD14 expression.(2)According to the pathological classification,TLR4,CD14 expression positive rate respectively 0-l level was 62.5%,2 level was 70.0% and 3 level was 75.0% and 4 level was 58.3%.TLR4,CD14 expression positive rate differences were statistically significant(P<0.05).(3)About 64.4% of PSS labial gland duct epithelial cells had the expression of TLR4,CD14,about 67.8% of the lymphatic in focal lymphocytic cells express TLR4,CD14,there was no statistically significant difference(P>0.05).(4)TLR4,CD14 mRNA expression of labial gland tissue in sjogren’s syndrome group was obviously higher than that of the control group (P<0.05).Conclusion:TLR4,CD14 in sjogren’s syndrome labial gland tissue increases,sjogren’s syndrome labial gland secretion of tissue damage,may exogenous infection start TLR4 and CD14 signaling pathways. Epithelial cells in the pathogenesis of sjogren’s syndrome,actively involve in the immune damage process.关键词
TLR4/CD14/唇腺组织Key words
TLR4/CD14/Salivary gland
