摘要
Abstract
Objective:To observe the clinical effect of Paroxetine in the treatment of diabetic patients with depression,and to determine the correlation between the level of cortisol and its treatment effect.Method:120 diabetic patients with depression in our hospital from January 2014 to January 2016 were observed as the research objects,cortisol increased groupin 52 cases,68 cases of normal cortisol group,two groups were treated with paroxetine,the clinical efficacy of patients was retrospectively analyzed.Result:The HAMD score was higher than that in normal group,HAMD reduction rate was significantly lower than that in normal group,the differences were statistically significant(P<0.05).The risk factors of depression in patients with comorbid diabetes elevated cortisol levels of HbA1c is more than 8%,more than 20 points of HAMD score and body mass index was greater than 25 kg/m2, age 35 to 50 years of age;the protective factors include exercise time per week for more than 4 h,the course of depression for more than 12 months.Conclusion:The depression risk factors in diabetic patients including glycosylated hemoglobin,HAMD score,body mass index,age,the need for the regulation and control of risk factors,take corresponding measures,so as to ensure the clinical therapeutic effect of paroxetine.关键词
抑郁症/糖尿病/皮质醇/帕罗西汀Key words
Depression/Diabetes/Cortisol/Paroxetine
