中国癌症防治杂志2016，Vol.8Issue(6)：360-363,364,5.DOI:10.3969/j.issn.1674-5671.2016.06.05
HIF-1α、CD44在胃癌组织中的表达及临床意义
Expression and clinical significance of both hypoxia-inducible factor(HIF)-1αand CD44 in gastric cancer
摘要
Abstract
Objective To investigate the relationship of expression of both HIF-1α and CD44 with clinicopathological features and outcomes in gastric cancer patients. Methods Tissue from 184 gastric cancer cases who underwent R0 resection were analyzed by immunohistochemistry to examine the expression of HIF-1αand CD44. Potential relationships of expression of HIF-1αand CD44 with clinicopathological features and prognosis were investigated. Results HIF-1αwas expressed in 102/184( 55.4%)of gastric cancer patients, and CD44 was expressed in 116/184( 62.4%) . HIF-1α and CD44 expression correlated with tumor invasion depth and lymphatic metastasis( P<0.05) ,and CD44 expression also correlated with tumor size( P<0.05) . Spearman rank correlation analysis indicated that HIF-1α expression positively correlated with CD44 expression ( r=0.71,P=0.003). Cox multivariate regression analysis indicated that tumor invasion depth, lymphatic metastasis, HIF-1α and CD44 expression were independent prognostic factors in gastric cancer patients ( P<0.05).Conclusions HIF-1α expression positively correlated with CD44 expression in gastric cancer patients,and expression of both proteins was related to poor prognosis.关键词
胃肿瘤/缺氧诱导因子1α/CD44/预后Key words
Gastrointestinal neoplasms/HIF-1α/CD44/Prognosis分类
医药卫生引用本文复制引用
黄名威,吴留成,覃宇周,李照,张猛,苏弟,陈建思..HIF-1α、CD44在胃癌组织中的表达及临床意义[J].中国癌症防治杂志,2016,8(6):360-363,364,5.基金项目
广西肿瘤学优势特色重点学科资助项目（024012002）；广西壮族自治区卫生厅自筹课题资助项目 （）
