中国癌症防治杂志2016，Vol.8Issue(6)：364-368,5.DOI:10.3969/j.issn.1674-5671.2016.06.06
ROS1在肺腺癌组织中的表达及临床意义
ROS1 expression in pulmonary adenocarcinoma and its clinical significance
摘要
Abstract
objective To detect the expression of ROS1 protein and its potential clinical significance in patients with pulmonary adenocarcinoma. Methods Formalin-fixed ,paraffin-embedded tissue microarrays prepared from 332 patients with pulmonary adenocarcinoma and 55 samples of adjacent normal lung tissue were analyzed for ROS1 expression using immunohistochemistry. Possible relationships were analyzed between ROS1 expression and clinicopathologic features or EGFR/ALK protein expression , as well as between protein expression and postoperative recurrence. Results The rate of ROS1 expression was 6% in pulmonary adenocarcinoma tissues and 0 in adjacent normal lung tissue( P<0.05) . ROS1 expression did not correlate with age or gender , but it did correlate significantly with smoking history and clinical stage( P<0.05) . Disease-free survival was 42 months in ROS1-negative patients and 19 months in ROS1-positive patients( P<0.05) . Rate of recurrence at 1 year was 30% in ROS1-negative patients and 13.5% in ROS1-positive patients ( P<0.05) . Conclusion Expression of ROS1 protein is low in pulmonary adenocarcinoma. ROS1 may be a prognostic factor that predicts risk of recurrence and metastasis of lung adenocarcinoma. Screening for ROS1 expression may help guide clinical treatment.关键词
肺肿瘤/ROS1/免疫组织化学染色/表皮生长因子/间变性淋巴瘤激酶/预后Key words
Lung neoplasms/ROS1/Immunohistochemistry/Epidermal growth factor receptor/Anaplastic lymphoma kinase/Prognosis分类
医药卫生引用本文复制引用
梁小芹,王卓,常守凤,张晓玲,陈城,王金穗,苏勤军..ROS1在肺腺癌组织中的表达及临床意义[J].中国癌症防治杂志,2016,8(6):364-368,5.基金项目
甘肃省科技支撑计划-社会发展类基金资助项目 （）
