中国癌症防治杂志2016，Vol.8Issue(6)：378-381,382,5.DOI:10.3969/j.issn.1674-5671.2016.06.09
乳腺癌子宫内膜转移3例临床病理分析
Clinical pathological analysis of endometrial metastasis of breast cancer
摘要
Abstract
Objective To investigate the clinical pathological characteristics, treatment and prognosis of endometrial metastasis of breast cancer,which is very rare. Methods This retrospective study analyzed the clinical data of 3 patients with endometrial metastasis of breast cancer treated at our hospital ,and relevant literature was reviewed. Results Two patients had breast-infiltrating lobular carcinoma ,while one patient had invasive ductal carcinoma. Endometrial metastatic lesions had a median diameter of 4.5 cm ( range,3-8 cm) . Cancer cells from endometrial metastatic lesions were round or oval under the microscope ,had dense cytoplasm and showed pleomorphism;tumor cells were arranged in tubular ,beam or funicular structures ,with lobular structures in some parts. Primary tumors and endometrial metastatic lesions in all three patients were positive for ER ,PR and Ki-67,while they showed variable staining for CerbB-2,GCDFP-15 and E-cadherin. Primary tumors and endometrial metastatic lesions were positive for p120 and CK7,but negative for CK5/6,SMA,CD10 and S-100. Conclusions Breast cancer patients with endometrial metastasis are rare and have poor prognosis and short survival time. Diagnosis is based mainly on medical history ,pathomorphology and immunophenotype. Staining for ER,PR,CK5/6,CK7,CerbB-2 and GCDFP-15 plays a role in differential diagnosis of uterine endometrial carcinoma in primary and metastatic cancer.关键词
乳腺肿瘤/子宫内膜转移/临床病理学/免疫组织化学/诊断Key words
Breast neoplasms/Endometrium metastasis/Clinical pathology/Immunohistochemistry/Diagnosis分类
医药卫生引用本文复制引用
孟令新,孟芹,周丹丹,王传艳,厉兵城,李昕,姚志刚..乳腺癌子宫内膜转移3例临床病理分析[J].中国癌症防治杂志,2016,8(6):378-381,382,5.基金项目
济宁医学院面上项目 （）
