中国医药科学2016，Vol.6Issue(21)：9-12,17,5.
石斛治疗血栓闭塞性脉管炎患者炎症细胞因子变化的观察
Observation changes of inflammatory cytokines in patients with thrombotic obliterans treated by dendrobium
摘要
Abstract
Objective To discuss iron caulis dendrobium prescription auxiliary treatment of thromboangiitis obliterans(TAO) in patients with clinical effect and interleukin 6(IL-6), interleukin 8(IL-8) and tumor necrosis factor alpha-α(TNF-α) level change and the effect. Methods Approved by hospital ethics committee, 62 cases of patients with TAO were selected and randomly divided into treatment group and control group with 31 cases in each. Patients in control group were only treated with western medicine drugs, and patients in treatment group were treated with iron caulis dendrobium prescription plus western medicine drugs. The course of the two group was three months. the clinical effect and the level of serum IL-6, IL-8 and TNF-α of the two groups before and after the treatment were compared. Results Clinical effective rate of treatment group was 96.8%, and the clinical effective rate of control was 93.5%, and the difference was not statistically significant betweem the two groups(χ2 = 0.553, P=0.553). The serum IL-6, IL-8 and TNF-αof treatment group before treatment were (4.25±2.71)ng/L, (826.0±97.3)ng/L and (4.62±2.3) ng/L, and the serum IL-6, IL-8 and TNFα of treatment group after treatment were (1.33±0.61)ng/L, (231.7±76.0) ng/L and (1.74±0.54)ng/L. The serum IL-6, IL-8 and TNF-α of control group before treatment were (4.18±2.35) ng/L, (852.4±84.5)ng/L and (4.43±2.16)ng/L, and the serum IL-6, IL-8 and TNF-α of control group after treatment were (3.57±2.16)ng/L, (619.8±73.4)ng/L and (3.97±1.61)ng/L. The average of serum IL-6, IL-8 and the level of TNF-α of the two groups were high before treatment, and after treatment, serum IL-6, IL-8 and the level of TNF-α of the two groups had varying degrees of reduction(P < 0.01). The average levels of serum IL-6 and IL-8 in treatment group were lower than those in control group(P < 0.01), which showed that the improvement of immune injury in treatment group was better than that in control group. Conclusion The effect of iron caulis dendrobium prescription auxiliary treatment of thromboangiitis obliterans (TAO) in improving clinical symptoms and inflammatory cytokine dysfunction in patients is better than pure western medicine treatment. It lays the foundation for improving the clinical curative effect.关键词
铁皮石斛/血栓闭塞性脉管炎/炎症细胞因子/瘀血阻络证Key words
Dendrobium/Thromboangiitis obliterans/Inflammatory cytokines/Blood-stasis obstruction分类
医药卫生引用本文复制引用
曾德创,邹才华,李近都,梁烨,罗仕官,陈宏明,唐习强,李天资..石斛治疗血栓闭塞性脉管炎患者炎症细胞因子变化的观察[J].中国医药科学,2016,6(21):9-12,17,5.基金项目
国家自然科学基金（81060028）；广西重大专项基金（桂科重1598005-9，桂科攻1355005-3-7）；广西高等学校科学研究资助项目（KY2015YB230）；广西壮族自治区百色市学研究资助项目（百科计20141104，2014069）。 （）
