中国医药科学2016，Vol.6Issue(21)：29-32,37,5.
ING4、PHDs在低氧性肺动脉高压大鼠中的表达及意义分析
The expression and significanceof ING4 and PHDs in hypoxic pulmonary hypertensive rats
摘要
Abstract
Objective To discuss the significance that the Expression of ING4 and PHDs in rats with hypoxic pulmonary hypertension. Methods To detect the value of RVHI、mPAP、HPVR of rat at different hypoxia time points by establishing rat model of hypoxic pulmonary hypertension. Results The mPAP of the experimental group was significantly higher than that of the blank control group(P<0.05) from the 7th day of hypoxia, and reached the highest value on the 14th day, and the RVHI of the rats began to increase and formed right ventricular hypertrophy and bureaucratic stenosis. The expression of ING4, PHD2 and PHD3 increased significantly at the 3rd day after hypoxia(P < 0.05), and HIF-1α did not change significantly at the beginning(P < 0.05). The expression of ING4 protein was significantly increased at the 7th day of hypoxia(P<0.05), PHD2 and PHD3(P<0.05), and the protein level of ING4 was significantly higher in the hypoxia group than that in the blank control group(P<0.05), and protein expression of HIF-1α increased at day 3 of hypoxia (P < 0.05), and the protein expression level of PHD1 did not change at the beginning of hypoxia until day 14. Compared with the blank control group, , And then maintained a low level(P < 0.05). Conclusion The Expression changes of ING4 and PHDs of Hypoxic pulmonary hypertension rats can affect the generation and development of hypoxic pulmonary hypertension.关键词
ING4/PHDs/低氧性肺动脉高压/大鼠Key words
INQA/PHDs/Hypoxic pulmonary hypertensive/Rats分类
医药卫生引用本文复制引用
孙永彪,朱佳,苏宗义,李丽,张忠双..ING4、PHDs在低氧性肺动脉高压大鼠中的表达及意义分析[J].中国医药科学,2016,6(21):29-32,37,5.基金项目
国家自然科学基金（81660271）；第十五期石河子大学大学生训练计划（SRP2017064）。 （）
