中国医药科学2016，Vol.6Issue(21)：33-37,5.
MMP-9在结直肠癌中的表达及临床意义
Expression of MMP-9 in colorectal carcinoma and its clinical significance
摘要
Abstract
Objective To investigate the expressions of matrix metalloproteinases (MMP-9) in colorectal carcinoma, and to analyze correlation between MMP-9 and invasion and metastasis of colorectal carcinoma. Methods 99 cases of colorectal carcinoma patients received radical resection in the Second Affiliated Hospital of Nanjing Medical University and Yancheng NO.3 People's Hospital from January 2007 to December 2010 were enrolled in our study. The expressions of MMP-9 in colorectal carcinoma and normal colorectal tissues were detected by using tissue chip technology combined with immunohistochemistry SP assay. The relations between the expressions of MMP-9 and clinicopathological features of colorectal carcinoma were analyzed. Results In colorectal carcinoma, the expression levels of MMP-9 was significantly higher than those of normal colorectal tissues (P<0.001). Patients with high stage of invasive depth, lymph node metastasis, and high linical stage showed obvious higher positive rates of MMP-9 than those of patients with low stage of invasive depth, without lymph node metastasis, and with low linical stage (P<0.05). It showed obvious negative correlation among MMP-9 and survival of patients with colorectal carcinoma. Patients with higher MMP-9 expression level in carcinoma tissues showed higher death rates (P < 0.05). Conclusion The expression of MMP-9 in colorectal carcinoma is closely related to the depth of tumor invasion, lymph node metastasis. MMP-9 can relex the progress of colorectal carcinoma, and judge the prognosis of patients with colorectal carcinoma.关键词
结直肠癌/MMP-9/临床意义Key words
Colorectal carcinoma/MMP-9/Clinical significance分类
医药卫生引用本文复制引用
金宁,张崇国,李红妍,王莉,李娟,王科明,王朝霞,王继荣..MMP-9在结直肠癌中的表达及临床意义[J].中国医药科学,2016,6(21):33-37,5.基金项目
江苏省高校自然科学研究面上项目（15KJB320006）。 （）
