中国医药科学2016，Vol.6Issue(21)：71-73,123,4.
万古霉素鞘内给药的药代动力学研究
Pharmacokinetics study of vancomycin in intrathecal administration
摘要
Abstract
Objective To investigate the pharmacokinetics of vancomyc in intrathecal administration, and to evaluate the safety of intrathecal administration of vancomycin. Methods Animal model of intrathecal catheterization rabbit was established. Vancomycin half-life determination was given on them. According to different doses, they were divided into three groups. After intrathecal administration of vancomycin, the drug concentration was determined by timed cerebrospinal fluid extraction until the end of 48 hours. Intermittent administration animals were divided into three groups according to the dose of vancomycin. Each group was injected vancomycin once daily for 3 days, and drug concentration was measured every 4H. Results In the high dose group, the concentration of the vancomyc reached the peak value at 4h, then decreased gradually, and the concentration of vancomyc fell to half its peak at 16h.The vancomyc almost metabolism completely after 48h. The vancomyc concentration-time curve of middle-dose group was basically similar to the high-dose group, but the peak was much lower than that of high-dose group, the time ofmetabolism faster. The low-dose group measured lower peak, metabolic half-life shorter. The drug concentration showed a rapid upward trend after each administration in the intermittent administration group. As time prolonged, The drug concentration decreased again, the three groups were not maintained at a more stable drug concentration. Conclusion The half-life of intrathecal injection is about 16 hours, and it is difficult to form a stable drug concentration in the cerebrospinal fluid by intermittent intrathecal injection.关键词
万古霉素/鞘内注射/药代动力学Key words
Vancomycin/Intrathecal administration/Pharmacokinetics分类
医药卫生引用本文复制引用
徐伟光,钟德泉,赵展,王文涛,贺龙双..万古霉素鞘内给药的药代动力学研究[J].中国医药科学,2016,6(21):71-73,123,4.基金项目
广东药学院附属第一医院联合基金（GYFYLH201325）。 （）
