中国医药科学2016，Vol.6Issue(21)：80-83,4.
胶滴肿瘤药敏检测技术对膀胱灌注化疗药物选择的临床研究
Clinical study of collagen gel droplet culture-drug sensitivity test for choosing intravesical chemotherapy of bladder cancer
摘要
Abstract
Objective To study the collagen gel droplet culture-drug sensitivity test(CD-DST)for choosing intravesical chemotherapy of bladder cancer. Methods According to the drug susceptibility testing technology,145 transurethral bladder cancer patients were divided into two groups.Group A used topiramate,doxorubicin,epirubici n, mitomycin,or gemcitabine chemotherapy and Group B used topiramate or doxorubicin without drug susceptibility testing.Comparing the basic data of patients,such as age,sex,smoking,tumor grade and tumor size.Tumor recurrence and recurrence interval can be found by using cox survival curve model. Results There were not significant differences in age(P=0.2915), sex(P=0.5268), smoking(P=0.8915),tumor grade(P=0.1931),and tumor size(P=0.1655),while it was statistically significant(P=0.0298<0.05)in terms of relapse rate.The use of the drug susceptibility method to select sensitive bladder perfusion,would delay tumor recurrence(χ2=6.663,P=0.0098<0.05). Conclusion CD-DST method of primary urothelial bladder cancer infusion chemotherapy sensitivity assay can effectively choose the sensitive chemotherapy drugs to effectively reduce the recurrence rate of bladder cancer in vitro.It is important to postpone the time of bladder cancer recurrence and effectively to choose intravesical individualized chemotherapy.关键词
膀胱灌注化疗/胶滴肿瘤药敏检测技术/药物选择/复发率/生存曲线分析Key words
Intravesical chemotherapy/The collagen gel droplet culture-drug sensitivity test(CD-DST)/Drug selection/Recurrence rate/Cox survival curve model分类
医药卫生引用本文复制引用
王美才,周荣升,周祥举,庞昆,韩从辉..胶滴肿瘤药敏检测技术对膀胱灌注化疗药物选择的临床研究[J].中国医药科学,2016,6(21):80-83,4.基金项目
江苏省重点研发计划（BE2015623）；江苏省“科教兴卫”工程医学重点人才科研项目（RC2011046）。 （）
