中国卒中杂志2017，Vol.27Issue(1)：23-28,6.DOI:10.3969/j.issn.1673-5765.2017.01.004
5，10-亚甲基四氢叶酸还原酶基因多态性与脑梗死患者颈动脉粥样硬化的相关性研究
Study on the Correlation between Polymorphism of 5,10 Methylenetetrahydrofolate Reductase Gene and Carotid Atherosclerosis in Patients with Cerebral Infarction
周浩 1魏守超 1赵兴军 1刘芳 1刘志辉1
作者信息
- 1. 261031 潍坊潍坊医学院神经病学教研室
- 折叠
摘要
Abstract
Objective To investigate the correlation between plasma homocysteine (Hcy) metabolism enzyme 5,10-methylenetetrahydrofolate reductaseC677T gene polymorphism and carotid atherosclerosis in patients with cerebral infarction. Methods The newly onset anterior circulation of large artery atherosclerotic infarction patients were enrolled into study group and patients without cerebral infarction during the clinical physical examination were taken as the control group. The level of plasma Hcy was measured by lfuorescence polarization immunoassay; color Doppler ultrasound examination of two groups of bilateral extracranial carotid artery atherosclerosis was used to determine whether there was a plaque and the nature of the plaque; and automatic gene chip was used to detect target population MTHFR C677T gene type. Results A total of 150 patients with newly onset anterior circulation cerebral infarction were enrolled into the study group and 100 cases were enrolled in the control group.①The frequency ofC677TMTHFR mutation (TT) genotype and T allele in the cerebral infarction group were signiifcantly higher than that in the control group (48.0%vs 19.0%,χ2=22.067,P<0.001; 64.0%vs 45.5%,χ2=6.907,P=0.009);②The mutation ofC677T CMTHFR and T gene in cerebral infarction group was positively correlated with the degree of carotid artery atherosclerosis stenosis (r=0.353,P<0.001);③The frequency ofC677T MTHFR mutation (TT) genotype and T allele were significantly higher in the unstable plaque group than in the stable plaque group in the cerebral infarction group (66.2%vs 34.1%,χ2=14.587,P<0.001; 77.5%vs 60.2%,χ2=6.978,P=0.008) . ConclusionMTHFR T gene mutation inC677T C site may be the risk factor of carotid atherosclerotic plaque instability and stenosis degree.关键词
颈动脉粥样硬化/基因多态性/同型半胱氨酸/血浆Key words
Carotid atherosclerosis/Gene polymorphism/Homocysteine/Plasma引用本文复制引用
周浩,魏守超,赵兴军,刘芳,刘志辉..5，10-亚甲基四氢叶酸还原酶基因多态性与脑梗死患者颈动脉粥样硬化的相关性研究[J].中国卒中杂志,2017,27(1):23-28,6.
