中国卒中杂志2017，Vol.27Issue(1)：89-93,5.DOI:10.3969/j.issn.1673-5765.2017.01.018
缺氧诱导因子-1α对脑梗死后内源性神经干细胞作用的研究进展
Research Progress of the Effects of Hypoxia Inducible Factor -1α on Endogenous Neural Stem Cells after Cerebral Infarction
摘要
Abstract
Neural stem cell has been used in the treatment of cerebral infarction because of its unique functions and advantages.Treatment of cerebral infarction with neural stem cells (NSCs) has no time window limit, no bleeding risk, and the transplanted cells can secrete a large number of nerve growth factors to improve the microenvironment, inhibit inlfammatory response, reduce apoptosis, promote nerve regeneration, and rebuild the damaged neural network. Hypoxia-inducible factor-1α (HIF-1α) is a key factor in the protective effects of cerebral ischemia and hypoxia, and its role in promoting the regeneration of NSCs after cerebral infarction is extensive and complex. In this paper, we will systematically review the important role of HIF-1α in promoting endogenous NSCs proliferation, migration and differentiation in the brain after cerebral ischemia and hypoxia injury, indicating that it may become the effective target of clinical treatment of cerebral infarction.关键词
缺氧诱导因子-1α/内源性神经干细胞/血管内皮生长因子/细胞基质衍生因子-1α/促红细胞生成素/脑梗死Key words
Hypoxia-inducible factor-1α/Neural stem cell/Vascular endothelial growth factor/Stromal cell-derived factor 1α/Erythropoietin/Cerebral infarction引用本文复制引用
林亚航,陈明,段淑荣..缺氧诱导因子-1α对脑梗死后内源性神经干细胞作用的研究进展[J].中国卒中杂志,2017,27(1):89-93,5.基金项目
黑龙江省自然科学基金重点项目（ZD201418）黑龙江省教育厅科学技术研究项目 （）
