中华灾害救援医学2017，Vol.5Issue(2)：86-90,5.DOI:10.13919/j.issn.2095-6274.2017.02.007
变应性鼻炎对小鼠嗅觉神经元的作用
Effect of allergic rhinitis on olfactory sensory neuron in mice
宋宫儒 1安丽娜 2彭碧波1
作者信息
- 1. 100039 北京，武警总医院 灾害救援医学研究所
- 2. 100039 北京，武警总医院 麻醉手术科
- 折叠
摘要
Abstract
Objective This study aimed to explore the effects of allergic rhinitis (AR) on olfactory sensory neurons (OSN) in mice. Methods An AR model of BALB/c mice was established by ovalbumin exposure (AR group, n=15), and wild-type BALB/c mice were set as the control group (n=15). The olfaction ability of the mice was detected by buried food pellet test (BFPT). The degree of OSN apoptosis in olfactory mucosa as well as its correlation with eosinophils were evaluated with the western blot analytical technique. Results (1) The mean time of BFPT in AR group was significantly longer than that the control group [(18.71±3.93)s vs (12.53±2.70) s, t=5.01,P<0.05];(2) When compared with the control group, the olfactory marker protein (OMP) of mature OSN in the nasal olfactory mucosa of AR group was significantly decreased (t=15.55, P<0.05), whereas Caspase-3 in apoptosis pathway and eosinophil peroxidase (EPX) protein were significantly increased (t=10.98, P<0.05;t=33.52, P<0.05);(3) There was a positive correlation between Caspase-3 and EPX proteins in the nasal olfactory mucosa of mice in AR group (r=0.78,P<0.05). Conclusions In the setting of AR, eosinophils infiltrated into olfactory mucosa induced sensorineural olfactory loss by exerting a detrimental effect on OSNs.关键词
变应性鼻炎/嗅觉减退/嗅觉神经元/嗜酸性粒细胞Key words
allergic rhinitis/olfactory loss/olfactory sensory neuron/eosinophil分类
医药卫生引用本文复制引用
宋宫儒,安丽娜,彭碧波..变应性鼻炎对小鼠嗅觉神经元的作用[J].中华灾害救援医学,2017,5(2):86-90,5.
