摘要
Abstract
Abdominal aortic aneurysms (AAA), is a vascular expansion caused by the injury of arterial wall, and vascular rupture will occur in the severe patients with a high mortality risk factor. AngiotensinⅡ(AngⅡ), as the primary bioactive peptide of the renin-angiotensin-system (RAS), is defined as a key mediator in the development of hypertension, atherosclerosis, and AAA. Therefore, Ang Ⅱ is widely used in the research of cardiovascular diseases and AAA in animal models. Many studies show that AngⅡplays a pivotal role in the initiation, progression and rupture of AAA, which may be associated with macrophages infiltration. Involvement of macrophages in vascular inflammation has been proven to be related to decrease of nitric oxide (NO) bioavailability, increase of reactive oxygen species products, inflammatory cytokines and matrix metalloproteinases (MMPs) secretion. This paper reviews the recent publications regarding the formation mechasim of AAA induced by macrophages and AngⅡ, which provides guidance for the future prevention and treatment of AAA.关键词
腹主动脉瘤/肾素血管紧张素系统/血管紧张素Ⅱ/巨噬细胞Key words
abdominalaortic aneurysm/renin-angiotensin-system/angiotensinⅡ/macrophagesn分类
医药卫生
