摘要
Abstract
Objective To investigate the risk factors of abnormal fetuses caused by ICP in pregnant women during pregnancy. Methods Totally 471 ICP pregnant women were selected in Chengdu Women' s and Children' s Central Hospital from January 2014 to June 2016, and retrospective analysis was conducted to analyze the risk factors of abnormal fetuses of ICP pregnant women. Results Single factor analysis showed that gestational weeks of ICP pregnant women (χ2 =38. 834,P=0. 000), occurrence time (χ2 =21. 470, P=0. 000), multiple pregnancy (χ2 =19. 529, P=0. 000), complicated by hypertension (χ2 =10. 963, P=0. 001), gestational diabetes mellitus (χ2 =7. 098, P=0. 008), complicated by hepatitis b (χ2 =5. 879, P =0. 015), ICP previous history (χ2 =7. 193, P =0. 007), biochemical indexes(TBA:χ2 =23. 410, P=0. 000; ALT, AST: χ2 =6. 114, P=0. 013; TBIL:χ2 =8. 204, P=0. 004; DBIL: χ2 =5. 361, P=0. 021) had relationship with occurrence rate of abnormal fetuses. Further multiple Logistic regression analysis revealed that occurrence time (OR =2. 92, 95%CI:1. 37 -6. 22), multiple pregnancy (OR =2. 29, 95%CI:1. 42 -3. 71), complicated by hypertension (OR=2. 41, 95%CI:1. 09-5. 33), gestational diabetes mellitus (OR=1. 95, 95%CI:1. 07-3. 56), TBA level (OR=2. 05,95%CI:1. 05-4. 01) were high risk factors of abnormal fetuses of ICP pregnant women. And gestational age of onset was the most important risk factor. Conclusion Occurrence time, multiple pregnancy, complicated by hypertension, gestational diabetes mellitus and TBA level are high risk factors of abnormal fetuses. Early detection, extensive monitoring and therapy for fetuses of ICP pregnant women, assessing whether pregnancy should be terminated and choosing suitable delivery mode according to gestational weeks and disease can improve maternal and perinatal outcomes.关键词
妊娠期/肝内胆汁淤积症/不良结局/危险因素Key words
gestation period/intrahepatic cholestasis of pregnancy ( ICP)/poor outcomes/risk factors分类
医药卫生
