中国妇幼健康研究2017，Vol.28Issue(2)：131-133,3.DOI:10.3969/j.issn.1673-5293.2017.02.011
彩色多普勒超声检查联合AFP、CK监测对产前胎盘植入诊断的价值研究
Value of color Doppler ultrasonography combined with AFP and CK monitoring on diagnosing prenatal placenta increta
摘要
Abstract
Objective To explore the diagnostic value of color Doppler ultrasonography combined with alpha fetal protein (AFP) and creatine kinase ( CK) on prenatal placenta increta. Methods Totally 120 cases of pregnant women in late pregnancy with high-risk factors of placenta increta were set in high-risk group and were checked by prenatal color Doppler ultrasound. They were divided into implant group (n=44) and no implant group (n=76) according to the pathological diagnosis after childbirth, and the difference between ultrasonic results and pathologic results were explored. Another 35 cases of healthy pregnant women in late pregnancy were set in control group. Serum AFP and CK were measured and the diagnostic value of individual ultrasonography, AFP and CK and joint detection of them on placenta increta was analyzed. Results Among 44 cases of placenta increta confirmed by pathological diagnosis, 15 cases were diagnosed with placenta increta by ultrasonography and 29 cases were missed diagnosed. Consistency analysis showed that ultrasonography in prenatal diagnosis of placenta increta had poor consistency with pathologic results (Kappa=0. 108, P>0. 05). The serum AFP and CK levels in implant group were significantly higher than those in no implant group and the control group, and the differences had statistical significance (t value was 16. 331, 15. 291, 16. 893 and 15. 763, respectively, all P<0. 05). The serum AFP and CK levels were not statistically different between implant group and the control group (t value was 1. 023 and 1. 278, respectively, both P>0. 05). Prenatal ultrasound diagnosis of placenta increta was low in sensitivity but high in specificity. Combination of AFP and CK could enhance the sensitivity of prenatal ultrasound diagnosis of placenta increta to 95. 45%. Conclusion Color Doppler ultrasonography in diagnosing placenta increta has certain value, but the missed diagnosis is high. The combination of serum AFP and CK monitoring may enhance the sensitivity to prenatal diagnosis of placenta increta, and it has vital significance.关键词
彩色多普勒超声/甲胎蛋白/肌酸激酶/胎盘植入/诊断Key words
color Doppler ultrasonography/alpha fetal protein ( AFP)/creatine kinase ( CK)/placenta increta/diagnosis分类
医药卫生引用本文复制引用
杨松玉,舒雪梅,周海慧,汤海燕,温翔..彩色多普勒超声检查联合AFP、CK监测对产前胎盘植入诊断的价值研究[J].中国妇幼健康研究,2017,28(2):131-133,3.基金项目
温州市2015年公益性科学计划资助项目(Y20150297) （Y20150297）
