摘要
Abstract
Objective To explore the effect of different doses of dexmedetomidine on perioperative hemodynamics and inflammatory factors in gynecologic laparoscopic surgery. Methods A total of 120 patients undergoing gynecological laparoscopic surgery during the period of June 2013 to April 2016 were selected and were randomly divided into high dose group (A1), low dose group (A2) and control group (C) with 40 cases in each. Patients in group A1 and group A2 were given 0. 8μg/( kg. h) and 0. 4μg/( kg. h) of dexmedetomidine after induction of anesthesia, respectively. Patients in group C were given saline solution. Heart rate ( HR) , mean arterial pressure ( MAP) , norepinephrine (NE), IL-6, IL-10 and TNF-α in serum were observed in each group at different time points of 10 min before anesthesia (T0), 1 min after tracheal intubation (T1), 5 min after pneumoperitoneum (T2) and the end of the surgery (T3). Results MAP, HR and NE were significantly different among three groups of patients in T1 and T2 ( F value ranged 3. 23 to 5. 47, respectively, all P<0. 05). HR and NE had significant differences (F value was 3. 27 and 3. 76, respectively, both P<0. 05), while there was no significant difference in MAP at T3 (F=1. 09, P>0. 05). MAP, HR and NE waves were minimum in group A1 while most volatile in group C at different time points. Three groups of patients were significantly different at T1, T2 and T3 in IL-6, IL-10 and TNF-α ( F value ranged 3. 31 to 5. 58, respectively, all P<0. 05). At T1, T2 and T3 IL-6 and TNF-αwere lowest but IL-10 was highest in group A1, while IL-6 and TNF-α were highest, but IL-10 was lowest in group C. Three groups of patients were not significantly different in pneumoperitoneum time and anesthesia recovery time (F value was 0. 559 and 1. 677, respectively, both P>0. 05). Conclusion Use of dexmedetomidine in gynecological laparoscopic surgery can reduce the perioperative inflammatory response, which is helpful to maintain hemodynamic stability. The dose of 0. 8μg/(kg. h) is significant.关键词
腹腔镜/右美托咪定/炎症因子/血流动力学Key words
laparoscopy/dexmedetomidine ( DEX)/inflammatory cytokines/hemodynamics分类
医药卫生
