中国实用神经疾病杂志2017，Vol.20Issue(3)：4-7,4.
高血压合并急性脑梗死患者血清细胞因子及同型半胱氨酸与脑梗死的关系
The relationship among cytokines and homocysteine in acute cerebral infarction patients complicating with hyper-tension
摘要
Abstract
Objective To investigate the differences and relationship among soluble intercellular adhesion molecule-1 (sI-CAM-1),macrophage colony-stimulating factor(M-CSF),oxidative modification of low density lipoprotein(ox-LDL)and homocys-teine (Hcy)in diabetes with acute cerebral infarction,for further understanding the pathogenesis of cytokines and homocysteine in acute cerebral infarction with hypertension.Methods One hundred acute cerebral infarction inpatients from January 2015 to Janu-ary 2016 were enrolled.The patients were divided into two subgroups A and B according to whether with hypertension mellitus or not,each group included 50 cases.One hundred healthy cases were selected as control group from the department of physical ex-amination.Serum level of lipids,glucose,homocysteine,liver and kidney function indexes were recorded.The ox-LDL,sICAM-1 , and M-CSF were measured by using the enzyme-linked immunosorbent assay(ELISA).The color Doppler ultrasound was used to detect carotid artery.Results Compared with the control group,the level of M-CSF ox-LDL,sICAM-1,Hcy in hypertension pa-tients with acute cerebral infarction group were all higher,differences were statistically significant(P<0.01);Hcy and acute cere-bral infarction associated cytokines Pearson correlation correlation analysis showed,M-CSF,ox-LDL,sICAM-1 had no significant correlations with Hcy(P>0.05).Conclusion M-CSF,ox-LDL,sICAM-1 and homocysteine in the hypertension patients may play important roles in the artery atherosclerosis leading to cerebral infarction process.Homocysteine may play a synergistic effect in atherosclerosis process.关键词
急性脑梗死/高血压/可溶性细胞间黏附分子-1/氧化修饰低密度脂蛋白/巨噬细胞集落刺激因子/同型半胱氨酸Key words
Acute cerebral infarction/Hypertension/Soluble intercellular adhesion molecule-1/Oxidized low density lipo-protein/Macrophage colony-stimulating factor/Homocysteine分类
医药卫生引用本文复制引用
莫志怀,陈瑶,王俊峰,张雷,雷俊杰..高血压合并急性脑梗死患者血清细胞因子及同型半胱氨酸与脑梗死的关系[J].中国实用神经疾病杂志,2017,20(3):4-7,4.基金项目
中国急性缺血性卒中治疗结局登记(编号:KLK-CBV-2015-001-C) （编号:KLK-CBV-2015-001-C）
