中国实用神经疾病杂志2017，Vol.20Issue(4)：19-21,3.
丁苯酞联合奥拉西坦治疗对急性脑梗死伴非痴呆型认知功能障碍的影响
Effects of butylphthalide combined with oxiracetam on treating acute cerebral infarction with cognitive impair-ment of none dementia
徐红强 1王艳玲 1孙利民1
作者信息
- 1. 河南新乡市第一人民医院神经内科 新乡 453000
- 折叠
摘要
Abstract
Objective To investigate the effects of butylphthalide combined with Oxiracetam in the treatment of acute cere-bral infarction(ACI)cognitive impairment of none dementia.Methods Totally 208 ACI cases with cognitive impairment of none dementia were randomly divided into study group and control group,and each group had 104 cases.On the basis of routine treat-ment,the control group took oxiracetam orally,800mg/time and 3 times/d.And the study group additionally took oral administra-tion of butylphthalide,two granules/time and 3 times/d.Before treatment and 3 months after treatment,neurological impairment was evaluated by NIHSS,the cognitive function was assessed by MoCA,and the modified Rankin scale and ADL were used to as-sess the quality of life.Results Before treatment both NIHSS scores and MoCA scores showed no statistical differences when we compared study group with control group(P >0.05),but three months later,the study group showed less NIHSS and mRS scores as well as more MoCA and ADL scores(all P <0.05).The incidence of adverse reactions in the study group and control group were 3.84% and 5.77%,respectively,and there was no significant difference between the two groups(P >0.05).Conclusion Bu-tylphthalide combined with oxiracetam can effectively improve neurological function,cognitive function and quality of life in ACI patients with cognitive impairment of none dementia with high safety.关键词
急性脑梗死/非痴呆型认知功能障碍/丁苯酞Key words
Acute cerebral infarction/Cognitive dysfunction of none dementia/Butylphthalide分类
医药卫生引用本文复制引用
徐红强,王艳玲,孙利民..丁苯酞联合奥拉西坦治疗对急性脑梗死伴非痴呆型认知功能障碍的影响[J].中国实用神经疾病杂志,2017,20(4):19-21,3.
