检验医学与临床2016，Vol.13Issue(z2)：32-33,2.DOI:10.3969/j.issn.1672-9455.2016.26.013
MicroRNA-124抑制实验性自身免疫性脑脊髓炎
The Suppression of MicroRNA-124 in EAE
摘要
Abstract
Objective MicroRNAs are a class of regulatory molecules related to many immune system physiological processes , including differentiation and activation .Brain-specific miR-124 is expressed in microglia .Then ,we examined the effect of microR-NA-124 on EAE .Methods Results We found that peripheral administration of miR-124 in EAE marked suppression of disease . Conclusion These findings identify miR-124 both as a key regulator of microglia quiescence in EAE and as a previously unknown modulator of monocyte and macrophage activation .关键词
microRNA-124/实验性自身免疫性脑脊髓炎/抑制Key words
MicroRNA-124/EAE/suppression引用本文复制引用
邱旸,渠滕,张庆,崔朝杰,赵文博..MicroRNA-124抑制实验性自身免疫性脑脊髓炎[J].检验医学与临床,2016,13(z2):32-33,2.基金项目
山东省医药卫生科技发展计划项目（2011QZ016）。 （）
