摘要
Abstract
Objective To analyze the distribution and drug resistance of pathogens causing nosocomia bloodstream infections in our hospital for three consecutive years retrospectively ,and provide a basis for the diagnosis and treatment of bloodstream Infec-tions .Methods Blood samples of inpatient in our hospital from Jan .2013 to Dec .2015 were cultured ,pathogens were isolated from positive alarm blood culture bottles ,pathogens identification and drug susceptibility test were performed by VITEK-Compact2 bac-terium measurement system .Results 381 strains of pathogens were isolated ,the detection rate was 9 .6% ,gram-negative bacilli ac-counted for 60 .4% and the detection rate of gram-negative bacilli was higher than that of gram-positive cocci .The top four patho-gens were Escherichia coli ,Klebsiella pneumoniae ,Staphylococcus aureus and Coagulase-negative staphylococci .The age of patients mainly concentrated in the 0-1 and 60-91 years old .Pathogens mainly distributed in Pediatrics ,ICU ,Blood purification division ,On-cology .The detected rates of E .coli and K .pneumoniae producing ESBLs were 55 .2% and 33 .8% ,The drug susceptibility of E .coli and K .pneumoniae producing ESBLs to Cefoxitin ,Amikacin ,Piperacillin/tazobactam were strong and these drugs could be used as experience .The detected rates of MRSA and MRSCN were 30 .0% and 52 .5% .The drug susceptibility of MRSA and MRSCN to Tetracycline ,Minocycline ,Moxifloxacin and Rifampicin were strong ,and The drug resistance of MRSA and MRSCN to Penicillins and Macrolides were high ,Vancomycin and Linezolid can be used as the first choice for the therapy in patients with severe blood-stream infection caused by Staphylococcus .Conclusion Pathogens causing nosocomia bloodstream infections were variety and the drug resistance were complex .Clinicians should raise the submission rate of blood and catheter .Laboratories should pay attention to the monitoring of pathogens and drug resistance .Laboratories should provide timely and accurate drug susceptibility results for Cli-nicians as soon as possible .Clinicians should choose antimicrobial agents rationally according for drug susceptibility results ,to con-trol the emergence and spread of drug resistant pathogens causing nosocomia bloodstream infections effectively .关键词
血流感染/血培养/病原菌/耐药性Key words
Bloodstream infection/Blood culture/Pathogen/Drug resistance
