摘要
Abstract
Objective To detect the expression level of associated cytokines of Th17 in Latent autoimmune diabetes in adults (LADA) ,and explore the inflammation pathological mechanism of these cells involved in the LADA .Methods To select 30 case of patients with LADA (LADA group) ,35 case of Type 2 diabetes patients(T2DM) ,30 healthy control group (control group) .The concentration of IL-23 ,IL-17 ,IL-6 ,associated with Th17 and IL-2 ,IL-10 with Treg cells in plasma were detected by enzyme linked immune-sorbent assay (ELISA) .in addition ,the correlation of all these cytokines and LADA metabolic parameters were analyzed by Pearson linear correlation were analyzed by Pearson linear correlation .Results Compared with healthy control group ,IL-23 ,IL-17 , IL-6 in LADA and T2DM group were significantly higher (P<0 .05) ,but higher in T2DM group than in LADA group ;the expres-sion level of IL-2 ,IL-10 were significantly lower in LADA group and T2DM group ,and lower in T2DM group than in LADA group (P<0 .05);The correlation analysis shows :IL-23 ,IL-17is positively correlated with fasting blood-glucose and negatively correlated with Fasting C peptide ,IL-10 is positively correlated with Fasting C peptide ,however ,We found no obvious correlation between IL-6 ,IL-2 and all parameters .Conclusion There is higher expression of Th17 cell cytokines ,which is involved in the pathogenesis of Latent autoimmune diabetes in adults .关键词
LADA/Th17/细胞因子Key words
Latent autoimmune diabetes in adults/Th17 cell/cytokines
