检验医学与临床2017，Vol.14Issue(2)：158-160,3.DOI:10.3969/j.issn.1672-9455.2017.02.003
脑肿瘤患者围术期凝血-纤溶相关指标及血小板水平变化
Changes of coagulation fibrinolysis indexes and platelet counts in patients with brain tumor during perioperative period
摘要
Abstract
Objective To observe dynamic changes of platelet (PLT ) count and coagulation fibrinolysis system in patients with cerebroma during perioperative period in department of neurosurgery .Methods A total of 73 patients with brain tumor were col‐lected from department of neurosurgery ,Beijing Tiantan Hospital .Fasting venous blood samples were collected before operation , first day and third day after operation .PLT counts ,plasma D‐dimer and FIB levels were detected ,and compared with healthy control group ,the changes were analyzed .Results The level of preoperative PLT in patients with brain tumor was lower than that in healthy control group ,but the difference was not statistically significant (P>0 .05) ,the level of D‐dimer and FIB were significantly higher than that of the healthy control group (P<0 .05) .On the first day after craniotomy ,PLT counts and FIB levels were signifi‐cantly decreased ,while D‐dimer level was significantly increased (P<0 .05) .At third day after craniotomy ,the level of PLT was still lower than that of preoperation ,FIB showed a trend of recovery ,and there was no significant difference compared with that pre‐operation (P>0 .05) .The D‐dimer remained at a high level ,but it was in a downward trend compared with first day after cranioto‐my(P<0 .05) .Conclusion There is an abnormal blood coagulation and fibrinolysis in patients with brain tumor during periopera‐tive period ,and it is important to monitor the blood coagulation and fibrinolysis indexes closely during perioperative period .关键词
脑肿瘤/围术期/D-二聚体/纤维蛋白原/凝血-纤溶系统Key words
cerebroma/perioperative period/D-dimer/fibrinogen/coagulation fibrinolytic system引用本文复制引用
张丽敏,郭雨童,曹磊,司学众,吕虹,方芳,张国军,康熙雄..脑肿瘤患者围术期凝血-纤溶相关指标及血小板水平变化[J].检验医学与临床,2017,14(2):158-160,3.基金项目
北京市卫生系统高层次卫生技术人才培养计划（2013-3-052）。 （）
